{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:23:44Z","timestamp":1790792624657,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31260501"],"award-info":[{"award-number":["31260501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Vernonia anthelmintica<\/jats:italic><\/jats:styled-content>(L.) Willd has been traditionally used in the treatment of vitiligo in Uyghur medicine. This study used butin, the main component of<jats:styled-content style=\"fixed-case\"><jats:italic>V.\u00a0anthelmintica<\/jats:italic><\/jats:styled-content>, to study the influence on hydroquinone\u2010induced vitiligo in mice. The animals were randomly divided into six groups: control, model, 8\u2010methoxypsoralen (8\u2010MOP, 4.25\u00a0mg\/kg), and butin (0.425, 4.25, and 42.5\u00a0mg\/kg) groups. The number of melanin\u2010containing hair follicles, basal layer melanocytes, melanin\u2010containing epidermal cells, the expression of tyrosinase (TYR) and tyrosinase\u2010related protein\u20101 (TRP\u20101), the malondialdehyde (MDA), and cholinesterase (CHE) activity in serum were measured. Our results indicated that compared with the model group, the melanin\u2010containing hair follicles, the expression of TYR and TRP\u20101 increased, the activity of CHE decreased after treatment with 8\u2010MOP and all doses of butin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), the basal layer melanocytes and melanin\u2010containing epidermal cells increased significantly after treatment with butin 4.25 and 42.5\u00a0mg\/kg (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), and the MDA activity decreased after using butin 4.25 and 42.5\u00a0mg\/kg and 8\u2010MOP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Our results support the use of butin on vitiligo, and its possible mechanisms may be related to increase the TYR and TRP\u20101 protein expression and decrease the activity of MDA and CHE in hydroquinone\u2010induced vitiligo model in mice. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5794","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T10:43:04Z","timestamp":1490092984000},"page":"740-746","source":"Crossref","is-referenced-by-count":38,"title":["The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone"],"prefix":"10.1002","volume":"31","author":[{"given":"Shi\u2010Xia","family":"Huo","sequence":"first","affiliation":[{"name":"Prescription Laboratory of Xinjiang Traditional Uyghur Medicine Xinjiang Institute of Traditional Uyghur Medicine Urumqi 830049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-5829","authenticated-orcid":false,"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Preclinical Medicine Research Center\/School of Pharmacy Southwest Medical University Luzhou 646000 China"},{"name":"Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-4645","authenticated-orcid":false,"given":"Xin\u2010Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Prescription Laboratory of Xinjiang Traditional Uyghur Medicine Xinjiang Institute of Traditional Uyghur Medicine Urumqi 830049 China"},{"name":"Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hui","family":"Ge","sequence":"additional","affiliation":[{"name":"Institute of Soil and Fertilizer &amp; Agricultural Water Conservation Xinjiang Academy of Agricultural Science Urumqi 830011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Prescription Laboratory of Xinjiang Traditional Uyghur Medicine Xinjiang Institute of Traditional Uyghur Medicine Urumqi 830049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ming","family":"Peng","sequence":"additional","affiliation":[{"name":"Prescription Laboratory of Xinjiang Traditional Uyghur Medicine Xinjiang Institute of Traditional Uyghur Medicine Urumqi 830049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[{"name":"Prescription Laboratory of Xinjiang Traditional Uyghur Medicine Xinjiang Institute of Traditional Uyghur Medicine Urumqi 830049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.55628"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb02900.x"},{"issue":"10","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.4049\/jimmunol.140.10.3438","article-title":"Immune studies in the depigmenting C57BL\/Ler\u2010vit\/vit mice. 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