{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:33:32Z","timestamp":1792506812434,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Panax ginseng<\/jats:italic><\/jats:styled-content> C.A. Meyer (Araliaceae) has been used in traditional Chinese medicine for enhancing cognition for thousands of years. Ginsenoside Rh1, a constituent of ginseng root, as with other constituents, has memory\u2010improving effects in normal mice and scopolamine\u2010induced amnesic mice. Sleep deprivation (SD) is associated with memory impairment through induction of oxidative stress. The present study investigated the effect of Rh1 against SD\u2010induced cognitive impairment and attempted to define the possible mechanisms involved. Ginsenoside Rh1 (20\u00a0\u03bcmol\/kg; 40\u00a0\u03bcmol\/kg) and modafinil (0.42\u00a0g\/kg) were administered to the mice intraperitoneally for 23\u00a0days. After 14\u2010day SD, locomotor activity was examined using the open field test, and the object location recognition and Morris water maze tests were used to evaluate cognitive ability. The cortex and hippocampus were then dissected and homogenized, and levels and activities of antioxidant defense biomarkers were evaluated to determine the level of oxidative stress. The results revealed that Rh1 prevented cognitive impairment induced by SD, and its ability to reduce oxidative stress in cortex and hippocampus may contribute to the mechanism of action. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5797","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T06:20:18Z","timestamp":1488262818000},"page":"763-770","source":"Crossref","is-referenced-by-count":51,"title":["Exploring the Effect of Ginsenoside Rh1 in a Sleep Deprivation\u2010Induced Mouse Memory Impairment Model"],"prefix":"10.1002","volume":"31","author":[{"given":"Cong","family":"Lu","sequence":"first","affiliation":[{"name":"Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Shi","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Dong","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Lv","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-1513","authenticated-orcid":false,"given":"Pan","family":"Xu","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[{"name":"National Laboratory of Human Factors Engineering\/The State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Qu","sequence":"additional","affiliation":[{"name":"National Laboratory of Human Factors Engineering\/The State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-4645","authenticated-orcid":false,"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"National Laboratory of Human Factors Engineering\/The State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.05.025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20806"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07175.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.09.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.06.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.11.017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968309348318"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02173-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200108000-00007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.04.017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408487101"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2012.36.4.342"},{"key":"e_1_2_6_14_1","first-page":"249","article-title":"Medical and genetic differences in the adverse impact of sleep loss on performance: ethical consideration for the medical profession","volume":"120","author":"Czeisler CA","year":"2009","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/227287a0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(88)90157-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.12.039"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:5:1:059"},{"key":"e_1_2_6_19_1","first-page":"373","article-title":"Neuroprotective role of melatonin in oxidative stress vulnerable brain","volume":"47","author":"GuptaYK GM","year":"2003","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/713755870","article-title":"Sleep loss and temporal memory","volume":"53","author":"Harrison Y","year":"2000","journal-title":"Q J Exp Psychol A"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1552"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709788803204"},{"key":"e_1_2_6_23_1","first-page":"128","article-title":"Effects of chronic partial sleep deprivation on growth and learning\/memory in young rats","volume":"11","author":"Jiang F","year":"2009","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2010.11.005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.072"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093781"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301534"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00374-8"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01528-X"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/216507990905700905","article-title":"The costs of short sleep","volume":"57","author":"Ohlmann KK","year":"2009","journal-title":"AAOHN J"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.07.006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200208070-00007"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(94)90071-X"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2003.11.032"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90240-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12099"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-008-9124-z"},{"key":"e_1_2_6_38_1","first-page":"116","article-title":"Characteristics of object location memory in mice: Behavioral and pharmalogical studies","volume":"90","author":"Takeshi M","year":"2006","journal-title":"Physiol & Behav"},{"key":"e_1_2_6_39_1","first-page":"106","article-title":"Experimental sleep deprivation as a tool to test memory deficits in rodents","volume":"7","author":"Valeria C","year":"2013","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08060FP"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3130"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(96)00363-0"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.039"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.07.051"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:25:33Z","timestamp":1696479933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/ptr.5797"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5797","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]}}}