{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:32:43Z","timestamp":1790501563601,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Morinda citrifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    , also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. citrifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti\u2010obesity, antibacterial and anti\u2010septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti\u2010nausea, anti\u2010gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti\u2010wrinkle and periodontal tissue regeneration activities. While it was concluded that although\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. citrifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    is widely and successfully used for the treatment or prevention of various diseases, it should be consumed carefully, and only after exhaustive studies into its chemical constituents and mechanisms of action, both in\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    models, as well as clinical trials. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/ptr.5817","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T06:59:27Z","timestamp":1495177167000},"page":"971-979","source":"Crossref","is-referenced-by-count":57,"title":["One Plant, Many Uses: A Review of the Pharmacological Applications of\n                    <scp>\n                      <i>Morinda citrifolia<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-3130","authenticated-orcid":false,"given":"Mylena Andr\u00e9a Oliveira","family":"Torres","sequence":"first","affiliation":[{"name":"Rede Nordeste de Biotecnologia\u2014RENORBIO, Ponto focal Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-3702","authenticated-orcid":false,"given":"Isadora","family":"de F\u00e1tima Braga Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Master's Degree in Animal Science Universidade Estadual do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-7986","authenticated-orcid":false,"given":"Renata","family":"Mond\u00eago\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia\u2014RENORBIO, Ponto focal Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-0244","authenticated-orcid":false,"given":"Joicy Cortez","family":"de S\u00e1","sequence":"additional","affiliation":[{"name":"Universidade Ceuma  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-986X","authenticated-orcid":false,"given":"Alessandra Lima","family":"Rocha","sequence":"additional","affiliation":[{"name":"Master's Degree in Animal Science Universidade Estadual do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-3725","authenticated-orcid":false,"given":"Ana Lucia","family":"Abreu\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology Universidade Estadual do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_2_29_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.163562"},{"key":"e_1_2_29_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np068065o"},{"key":"e_1_2_29_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5063540"},{"key":"e_1_2_29_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204380"},{"key":"e_1_2_29_6_1","first-page":"85","article-title":"Anti\u2010oxidant activity of \n                     Morinda citrifolia\n                   on lymphoma\u2010bearing mice","volume":"26","author":"Anitha T","year":"2006","journal-title":"Anc Sci 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