{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:48:36Z","timestamp":1772722116815,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jiangsu Provincial Key&D special Fund","award":["BE2015666"],"award-info":[{"award-number":["BE2015666"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Qilin pill has been used in the management of oligoasthenospermia. This meta\u2010analysis aimed to evaluate the effects of Qilin pill as an adjunctive therapy on semen parameters in oligoasthenospermic men. A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, Wanfang, CNKI, and VIP databases until June 2016. Randomized controlled trials (RCTs) that evaluated Qilin pill as an adjunctive therapy in oligoasthenospermic were included. Dichotomous data and continuous data were calculated as the risk ratio (RR) and mean difference (MD) with their 95% confidence interval (CI), respectively. Eight RCTs involving 778 patients were identified. Adjunctive treatment with Qilin pill significantly improved the semen volume (MD 0.50\u00a0mL; 95% CI 0.42\u20130.59), sperm concentration (MD 5.01\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup>\/mL; 95% CI 3.28\u20136.75), sperm motility (MD 7.54%; 95% CI 5.64\u20139.45), grade A sperm (MD 9.75%; 95% CI 4.05\u201315.45), serum testosterone level (MD 1.66\u00a0nM; 95% CI 0.40\u20132.92), and pregnancy rate (RR 1.46; 95% CI 1.08\u20131.99) during follow\u2010up. However, differences in the serum follicle\u2010stimulating and luteinizing hormone levels were not significant. Adjunctive treatment with Qilin pill significantly improves the sperm quality in patients with oligoasthenospermia. However, further trials are necessary to investigate the efficacy of Qilin pill on oligoasthenospermia\u2010induced male infertility. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5854","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T05:52:46Z","timestamp":1498024366000},"page":"1291-1297","source":"Crossref","is-referenced-by-count":14,"title":["Adjuvant Treatment with Qilin Pill for Men with Oligoasthenospermia: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"31","author":[{"given":"Xin","family":"Jin","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Translational Medicine, The Affiliated People's Hospital Jiangsu University  Zhenjiang Jiangsu 212002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changfeng","family":"Man","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Translational Medicine, The Affiliated People's Hospital Jiangsu University  Zhenjiang Jiangsu 212002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Translational Medicine, The Affiliated People's Hospital Jiangsu University  Zhenjiang Jiangsu 212002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-8427","authenticated-orcid":false,"given":"Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Translational Medicine, The Affiliated People's Hospital Jiangsu University  Zhenjiang Jiangsu 212002 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