{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:32:43Z","timestamp":1777617163612,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Current strategies to control leishmaniasis are mainly based on chemotherapy. However, none of the available drugs can be considered to be ideal to treat this disease. Because of the hydrophobic nature and bioactivities of their components, essential oils (EOs) can be considered as important sources for developing agents against intracellular pathogens, such as <jats:italic>Leishmania<\/jats:italic> parasites. In this study, we report the chemical characterization, antileishmanial activities, and cytotoxicity effect of the EO from <jats:italic>Pluchea carolinensis<\/jats:italic> (Jacq.) G. Don. (Asteraceae). Chemical analysis revealed that EO from aerial part from <jats:italic>P.\u00a0carolinensis<\/jats:italic> is composed of 44 compounds. The main component was selin\u201011\u2010en\u20104<jats:italic>\u03b1<\/jats:italic>\u2010ol, which made up 51.0%. <jats:italic>In vitro<\/jats:italic> antileishmanial studies showed that <jats:italic>P.\u00a0carolinensis<\/jats:italic> EO inhibited the growth of promastigotes (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a024.7\u00a0\u00b1\u00a07.1\u00a0\u03bcg\/mL) and amastigotes (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a06.2\u00a0\u00b1\u00a00.1\u00a0\u03bcg\/mL) of <jats:italic>Leishmania amazonensis<\/jats:italic>, while cytotoxicity evaluation revealed fivefold higher values than those for the parasites. In a model of experimental cutaneous leishmaniasis in BALB\/c mice, five doses of EO at 30\u00a0mg\/kg by intralesional route demonstrated smaller lesion size and parasite burden (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) compared with animals treated with Glucantime\u00ae and untreated mice. In conclusion, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> results showed the potentialities of EO from <jats:italic>P.\u00a0carolinensis<\/jats:italic> with the future possibility of a new alternative in the treatment for leishmaniasis. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5869","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T12:17:54Z","timestamp":1499948274000},"page":"1419-1426","source":"Crossref","is-referenced-by-count":22,"title":["Chemical Characterization, Antileishmanial Activity, and Cytotoxicity Effects of the Essential Oil from Leaves of <scp><i>Pluchea carolinensis<\/i><\/scp> (Jacq.) G. Don. (Asteraceae)"],"prefix":"10.1002","volume":"31","author":[{"given":"Marley","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Parasitology Department Institute of Tropical Medicine \u201cPedro Kouri\u201d  Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Scull","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Pharmacy and Food Havana University  Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabodh","family":"Satyal","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama in Huntsville  Huntsville AL 35899 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-0528","authenticated-orcid":false,"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama in Huntsville  Huntsville AL 35899 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianet","family":"Monzote","sequence":"additional","affiliation":[{"name":"Parasitology Department Institute of Tropical Medicine \u201cPedro Kouri\u201d  Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry","author":"Adams RP","year":"2007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00809-10"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2007.08.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.106"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh058"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.12.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.9.2167"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.03.022"},{"key":"e_1_2_6_10_1","article-title":"In vitro antileishmanial activity of essential oil of Vanillosmopsis arborea (Asteraceae) Baker","volume":"7","author":"Colares AV","year":"2013","journal-title":"Evid. 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