{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:02:11Z","timestamp":1780513331407,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,12]],"date-time":"2017-11-12T00:00:00Z","timestamp":1510444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>HT042 is a standardized functional food ingredient approved by Korean Food and Drug Administration with a claim \u2018HT042 can help height growth of children\u2019. We aimed to evaluate the safety and efficacy of HT042 on height growth in children with mild short stature. A multicenter, randomized, double\u2010blind, placebo\u2010controlled parallel study was performed on children aged 6\u20138\u00a0years with height ranked below the 25th percentile. In 129 children, height gain was significantly higher in HT042 group than placebo group after 24\u00a0weeks (mean difference, 0.29\u00a0cm; 95% CI, 0.01 to 0.57\u00a0cm; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027). The difference was elevated when the efficacy analysis was restricted to children below the 10th percentile (mean difference, 0.45\u00a0cm; 95% CI, 0.04 to 0.87\u00a0cm; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.031). Because bone age advancement was lower in HT042 group, height standard deviation score gain for bone age was higher in HT042 group and the difference was significant in children below the 10th percentile (mean difference, 0.20 score; 95% CI, 0.00 to 0.39 points; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.045). Serum IGF\u20101 and IGFBP\u20103 levels were significantly increased compared with baseline within HT042 group, but group difference was not significant. HT042 supplementation helped to increase height growth in children without skeletal maturation and was more effective in much shorter children. The effects might be mediated by increases in serum IGF\u20101 and IGFBP\u20103 levels. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5886","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:32:36Z","timestamp":1510533156000},"page":"49-57","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Astragalus Extract Mixture HT042 on Height Growth in Children with Mild Short Stature: A Multicenter Randomized Controlled Trial"],"prefix":"10.1002","volume":"32","author":[{"given":"Donghun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Herbal Pharmacology Kyung Hee University College of Korean Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Haeng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyung Hee University College of Korean Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungbin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Herbal Pharmacology Kyung Hee University College of Korean Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Jung","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-3298","authenticated-orcid":false,"given":"Gyu Tae","family":"Chang","sequence":"additional","affiliation":[{"name":"Pediatrics of Korean Medicine Kyung Hee University Hospital at Gangdong  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,12]]},"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:19:25Z","timestamp":1695961165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/ptr.5886"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5886","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,12]]}}}