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Delayed onset muscle soreness is a multifactorial process involving both mechanical and biochemical components, associated with clinical features that may limit range of motion, and athletes seek for effective recovery strategies to optimize future training sessions. TensLess<jats:sup>\u00ae<\/jats:sup> is a food supplement developed to help manage post\u2010exercise recovery. The supplement has been investigated on 13 recreationally active athletes of both sex, during a randomized, double\u2010blind, and crossover clinical investigation, including a 3\u2010week washout period. The clinical investigation was based on the study of TensLess<jats:sup>\u00ae<\/jats:sup> effects for DOMS management and on the reduction of associated muscle damages following an eccentric exercise protocol. Supplementation with TensLess<jats:sup>\u00ae<\/jats:sup> induced significant decrease in DOMS perception (\u221233%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) as of the first 24\u00a0h; this was significantly correlated with a lowered release of muscle damage\u2010associated biomarkers, namely myoglobin, creatinine, and creatine kinase, for the whole length of the recovery period. Taken together, these positive results clearly indicate that post\u2010exercise supplementation with TensLess<jats:sup>\u00ae<\/jats:sup> may preserve myocytes and reduce soreness following eccentric exercise\u2010induced damages, and, accordingly, significantly shorten muscle recovery. 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