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Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan\u2010induced diabetic rats were treated for 60\u00a0days with a hydroalcoholic extract of<jats:styled-content style=\"fixed-case\"><jats:italic>M. paniculata<\/jats:italic><\/jats:styled-content>(MPE), at doses of 100, 200, and 400\u00a0mg\/kg. MPE decreased glycemia and also cholesterol and triglyceride levels, starting 1\u00a0week after treatments, as compared with the same group before treatments. Glucose values were reduced toward normality after 1\u00a0week of treatment. MPE hypoglycemic effects were potentiated by glibenclamide and metformin. MPE also decreased fructosamine and glycated hemoglobin values. MPE reduced diabetes\u2010induced morphological alterations of the kidney, pancreas, and liver. MPE acts similarly to glibenclamide and metformin, and its glucose\u2010lowering action is partly a consequence of ATP\u2010sensitive K<jats:sup>+<\/jats:sup>channel inhibition. MPE may be a potential therapeutic alternative for the treatment of diabetes and its complications. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5903","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T08:02:38Z","timestamp":1503648158000},"page":"1747-1756","source":"Crossref","is-referenced-by-count":11,"title":["<scp><i>Murraya paniculata<\/i><\/scp>(L.) 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