{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:35:53Z","timestamp":1770413753340,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>The metabolic syndrome (MetS) is a multicomponent condition with a complex etiology involving genetic and environmental factors. Artichoke leaf extract (ALE) has shown favorable effects on lipid and glucose metabolism. The present study aimed to investigate the effects of ALE supplementation on metabolic parameters in women with MetS, using a nutrigenetics approach. In this double\u2010blind randomized clinical trial, 50 women (aged 20\u201350\u00a0years) with MetS were randomly allocated into the two groups: \u201cALE group\u201d (received 1,800\u00a0mg hydroalcoholic extract of artichoke as four tablets per day) and \u201cplacebo group\u201d (received placebo consisted of corn starch, lactose, and avicel as four tablets per day) for 12\u00a0weeks. The biochemical and anthropometric parameters were determined before and after the intervention. The FTO\u2010rs9939609 and the TCF7L2\u2010rs7903146 polymorphisms were genotyped by polymerase chain reaction\u2010restriction fragment length polymorphism. In carriers of A allele of the FTO\u2010rs9939609, ALE supplementation resulted in a statistically significant decrease in serum triglyceride level compared with placebo (\u221219.11% vs. 10.83%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), with no other significant differences between the two groups. The TCF7L2\u2010rs7903146 polymorphism showed no interaction with response to ALE (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO\u2010rs9939609 polymorphism in women with MetS.<\/jats:p>","DOI":"10.1002\/ptr.5951","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:40:14Z","timestamp":1511977214000},"page":"84-93","source":"Crossref","is-referenced-by-count":30,"title":["Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2\u2010rs7903146 and FTO\u2010rs9939609 polymorphisms"],"prefix":"10.1002","volume":"32","author":[{"given":"Khatereh","family":"Rezazadeh","sequence":"first","affiliation":[{"name":"Talented Students Center, Student Research Committee, School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Rahmati\u2010Yamchi","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Mohammadnejad","sequence":"additional","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-1289","authenticated-orcid":false,"given":"Mehrangiz","family":"Ebrahimi\u2010Mameghani","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Delazar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.9874"},{"key":"e_1_2_9_4_1","first-page":"426","article-title":"Appropriate definition of metabolic syndrome among Iranian adults: Report of the Iranian National Committee of Obesity","volume":"13","author":"Azizi F.","year":"2010","journal-title":"Archives of Iranian Medicine"},{"key":"e_1_2_9_5_1","article-title":"Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence","author":"Chen L.","year":"2017","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0955"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.057"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3285"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1466"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8130"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151710"},{"key":"e_1_2_9_14_1","volume-title":"Ministry of health","author":"Ghasemi D. 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