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Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants:<jats:styled-content style=\"fixed-case\"><jats:italic>Silybum marianum<\/jats:italic><\/jats:styled-content>(L.) Gaertn.,<jats:italic><jats:styled-content style=\"fixed-case\">Glycyrrhiza glabra<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">Phyllanthus amarus<\/jats:styled-content><\/jats:italic>Schumach. &amp; Thonn.,<jats:italic>Salvia miltiorrhiza<\/jats:italic>Bunge.,<jats:italic>Astragalus membranaceus<\/jats:italic>(Fisch.) Bunge<jats:italic>,<jats:styled-content style=\"fixed-case\">Capparis spinosa<\/jats:styled-content><\/jats:italic>(L.),<jats:styled-content style=\"fixed-case\"><jats:italic>Cichorium intybus<\/jats:italic><\/jats:styled-content>(L.)<jats:italic>,<jats:styled-content style=\"fixed-case\">Solanum nigrum<\/jats:styled-content><\/jats:italic>(L.)<jats:italic>,<jats:styled-content style=\"fixed-case\">Sapindus mukorossi<\/jats:styled-content><\/jats:italic>Gaertn.<jats:italic>,<jats:styled-content style=\"fixed-case\">Ginkgo biloba<\/jats:styled-content><\/jats:italic>(L.),<jats:italic>Woodfordia fruticosa<\/jats:italic>(L.) Kurz<jats:italic>,<jats:styled-content style=\"fixed-case\">Vitex trifolia<\/jats:styled-content><\/jats:italic>(L.)<jats:italic>, Schisandra chinensis<\/jats:italic>(Turcz.) Baill.,<jats:italic>Cuscuta chinensis<\/jats:italic>(Lam.),<jats:italic><jats:styled-content style=\"fixed-case\">Lycium barbarum<\/jats:styled-content>, Angelica sinensis<\/jats:italic>(Oliv.) Diels, and<jats:italic>Litsea coreana<\/jats:italic>(H. Lev<jats:italic>.<\/jats:italic>). The probable modes of action of these plants include immunomodulation, stimulation of hepatic DNA synthesis, simulation of superoxide dismutase and glutathione reductase to inhibit oxidation in hepatocytes, reduction of intracellular reactive oxygen species by enhancing levels of antioxidants, suppression of ethanol\u2010induced lipid accumulation, inhibition of nucleic acid polymerases to downregulate viral mRNA transcription and translation, free radical scavenging and reduction of hepatic fibrosis by decreasing the levels of transforming growth factor beta\u20101, and collagen synthesis in hepatic cells. However, further research is needed to identify, characterize, and standardize the active ingredients, useful compounds, and their preparations for the treatment of liver diseases.<\/jats:p>","DOI":"10.1002\/ptr.5957","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T07:00:36Z","timestamp":1508396436000},"page":"199-215","source":"Crossref","is-referenced-by-count":118,"title":["Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-0663","authenticated-orcid":false,"given":"Muhammad","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"},{"name":"Department of Biotechnology University of Malakand Chakdara Dir (L)\u201018000 Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneez","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qurat ul Ain","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ovais","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Talha","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abida","family":"Raza","sequence":"additional","affiliation":[{"name":"National Institute of Laser and Optronics Nilore 45650 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabta Khan","family":"Shinwari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Idrees","sequence":"additional","affiliation":[{"name":"Hazara University Mansehra Khyber Pakhtunkhwa 21120 Pakistan"},{"name":"Center for Applied Molecular Biology (CAMB) University of the Punjab Lahore 53700 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4269\/ajtmh.1998.59.571","article-title":"Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: Identification of two novel hepatitis C virus subtypes","volume":"59","author":"Abdulkarim A. 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