{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:18:48Z","timestamp":1790101128946,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Laila Nutraceuticals, Vijayawada, Andhra Pradesh, India","award":["C090001"],"award-info":[{"award-number":["C090001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>LI13109F is a novel herbal composition containing the extracts of<jats:styled-content style=\"fixed-case\"><jats:italic>Boswellia serrata<\/jats:italic><\/jats:styled-content>gum resin and<jats:styled-content style=\"fixed-case\"><jats:italic>Aegle marmelos<\/jats:italic><\/jats:styled-content>fruit. This composition dampens leukotriene dependent inflammatory reactions via inhibiting 5\u2010lipoxygenase pathway. In a Sephadex LH\u201020 induced airway inflammation model of Sprague Dawley rats, LI13109F significantly reduced infiltrated granulocyte population in the bronco\u2010alveolar lavage fluid and normalized Th1\/Th2 cytokine balance. Further, a 56\u2010day placebo\u2010controlled and randomized double blind study (Clinical Trial Registration No. CTRI\/2016\/10\/007393) on subjects with mild to moderate asthma has evaluated the clinical efficacy of LI13109F. The study subjects received either 200\u00a0mg\/day of LI13109F (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) or a similar dosage of placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a018). At the end of the trial period, LI13109F conferred significant improvements in the clinical parameters; the emotional function (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0305) and asthma symptoms scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0002) were improved even at 14\u00a0days, compared with the placebo. Further, 56\u00a0days supplementation of LI13109F resulted in significant increase in serum IFN\u2010\u03b3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0014) and reduction in IL\u20104 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0497), compared with placebo. LI13109F supplementation did not yield any serious adverse events or any abnormal observations in routine laboratory examinations during the study. Together, these observations suggest that LI13109F (AlvioLife\u00ae) is tolerable and an effective intervention for management of mild to moderate asthma such as airway inflammation.<\/jats:p>","DOI":"10.1002\/ptr.5963","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T08:36:35Z","timestamp":1512549395000},"page":"140-150","source":"Crossref","is-referenced-by-count":17,"title":["A novel herbal composition containing extracts of<i>Boswellia serrata<\/i>gum resin and<i>Aegle marmelos<\/i>fruit alleviates symptoms of asthma in a placebo controlled double\u2010blind clinical study"],"prefix":"10.1002","volume":"32","author":[{"given":"Pothina","family":"Yugandhar","sequence":"first","affiliation":[{"name":"Department of Pulmonology ASR Academy of Medical Sciences Eluru Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konda Manikyeswara","family":"Rao","sequence":"additional","affiliation":[{"name":"Suraksha Health Village Gurunanak Nagar Vijayawada Andhra Pradesh 520008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-2621","authenticated-orcid":false,"given":"Krishanu","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Laila Nutraceuticals R&amp;D Center Vijayawada Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0081-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.004184"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.foodres.2011.02.008","article-title":"Phytochemistry and medicinal uses of the bael fruit (Aegle marmelos Correa): A concise review","volume":"44","author":"Baligaa M. 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