{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:51:30Z","timestamp":1791805890455,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81773870"],"award-info":[{"award-number":["No.81773870"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Gentiopicroside isolated from <jats:italic>gentiana macrophylla<\/jats:italic> Pall. belongs to iridoid glycosides. This study aimed to evaluate the protective effect of gentiopicroside against ethanol\u2010induced gastric mucosal injury in mice. Mice were proactively administrated with gentiopicroside by intragastric administration once a day for 3 consecutive days. On the 3rd day, gastric ulcer in mice was induced with 70% ethanol after the last intragastric administration. The stomach tissues were submitted for evaluation of the severity of gastric mucosal alterations. Gentiopicroside administrated orally ameliorated the severity of gastric mucosal alterations. Oral administration of gentiopicroside significantly increased heat shock protein\u201070 and glutathione levels and superoxide dismutase activity, normalized epidermal growth factor and vascular endothelial growth factor levels, and decreased the levels of tumour necrosis factor\u2010\u03b1, interleukin\u20106 and malondialdehyde, and myeloperoxidase activity in gastric tissue. These findings demonstrated that gentiopicroside has protective effect against ethanol\u2010induced gastric mucosal injury in mice through the improvements of antioxidative and anti\u2010inflammatory effects, as well as up\u2010regulation of heat shock protein\u201070 level and normalization of epidermal growth factor and vascular endothelial growth factor levels. The results presented in this study provide some evidence for the development of a novel antigastric ulcer agent.<\/jats:p>","DOI":"10.1002\/ptr.5965","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T09:08:57Z","timestamp":1512983337000},"page":"259-266","source":"Crossref","is-referenced-by-count":41,"title":["Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol\u2010induced gastric mucosal injury in mice"],"prefix":"10.1002","volume":"32","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education Northwest University  Xi'an 710069 China"},{"name":"Biomedicine Key Laboratory of Shaanxi Province, College of Life Science Northwest University  Xi'an 710069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Wang","sequence":"additional","affiliation":[{"name":"Key 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