{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:33:13Z","timestamp":1788777193946,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["94\u20107621"],"award-info":[{"award-number":["94\u20107621"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    Our aim is to assess the effect of cinnamon powder capsules on insulin resistance, anthropometric measurements, glucose and lipid profiles, and androgens of women with polycystic ovarian syndrome (PCOS). Out of 80 women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in this randomized double\u2010blind placebo\u2010controlled clinical trial. All of the PCOS women were taking medroxy progesterone acetate 10\u00a0mg\/day for the last 10\u00a0days of their menstrual cycles. The cases were randomly allocated to 2 groups. The women in the first group were treated by cinnamon powder capsules 1.5\u00a0g\/day in 3 divided doses for 12\u00a0weeks and the second group by similar placebo capsules. Anthropometric measurements, fasting blood sugar, fasting insulin, blood glucose 2\u00a0hr after taking 75\u00a0g oral glucose, HbA1c, testosterone, dehydroepiandrosterone sulphate, homeostatic model assessment for insulin resistance, triglyceride, and cholesterol (low\u2010density lipoprotein, high\u2010density lipoprotein, and total) before and after the intervention were evaluated and compared as outcome measures. Fasting insulin (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.024) and homeostatic model assessment for insulin resistance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.014) were reduced after 12\u00a0weeks in the cinnamon group compared with the placebo. There was also a significant decrease in low\u2010density lipoprotein in cinnamon group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.004) as compared with baseline that caused significant difference with placebo (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.049). However, changes in other outcome measurements did not lead to statistically significant difference with placebo. The present results suggest that complementary supplementation of cinnamon significantly reduced fasting insulin and insulin resistance in women with PCOS.\n                  <\/jats:p>","DOI":"10.1002\/ptr.5970","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:42:51Z","timestamp":1513557771000},"page":"276-283","source":"Crossref","is-referenced-by-count":91,"title":["Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double\u2010blind placebo controlled clinical trial"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1434-8599","authenticated-orcid":false,"given":"Mahdie","family":"Hajimonfarednejad","sequence":"first","affiliation":[{"name":"Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Nimrouzi","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-0936","authenticated-orcid":false,"given":"Mojtaba","family":"Heydari","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-4993","authenticated-orcid":false,"given":"Mohammad Mehdi","family":"Zarshenas","sequence":"additional","affiliation":[{"name":"Medicinal Plants Processing Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Raee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, School of Pharmacy, and Pharmaceutical Sciences Research Centre Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahia Namavar","family":"Jahromi","sequence":"additional","affiliation":[{"name":"Infertlity Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Obstetrics and Gynecology, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Maternal\u2010fetal medicine research center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.023"},{"issue":"8","key":"e_1_2_8_3_1","first-page":"671","article-title":"Identification of essential oil components by gas chromatography\/mass spectroscopy","volume":"6","author":"Adams R.","year":"1997","journal-title":"Journal of the American Society for Mass Spectrometry"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03079.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4089"},{"issue":"8","key":"e_1_2_8_6_1","first-page":"611","article-title":"Metformin versus chromium picolinate in clomiphene citrate\u2010resistant patients with PCOs: A double\u2010blind randomized clinical trial","volume":"11","author":"Amooee S.","year":"2013","journal-title":"Iranian journal of reproductive medicine"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf034916b"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13779"},{"issue":"1","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-511","article-title":"Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo\/amenorrhoea and hyperandrogenism; 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