{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:25:56Z","timestamp":1769066756891,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["12401900300"],"award-info":[{"award-number":["12401900300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14401901900"],"award-info":[{"award-number":["14401901900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p><jats:italic>Fructus Arctii<\/jats:italic> (great burdock achene) is the dried ripe fruit of <jats:styled-content style=\"fixed-case\"><jats:italic>Arctium lappa<\/jats:italic><\/jats:styled-content> L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of <jats:italic>Fructus Arctii<\/jats:italic> resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from <jats:italic>Fructus Arctii<\/jats:italic> (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0.5% sodium carboxymethyl cellulose), TLFA (250 and 125\u00a0mg\/kg), or metformin (200\u00a0mg\/kg) for 11\u00a0weeks, and C57BL\/6J mice treated with saline solution (0.9%, <jats:italic>w<\/jats:italic>\/<jats:italic>v<\/jats:italic>) were used as normal control. The results indicate that TLFA has dual effects of hypoglycemia and weight loss, and administration of TLFA in KKAy mice could decrease fasting blood glucose, glycated hemoglobin, and body weight; improve oral glucose tolerance; increase high density lipoprotein cholesterol; and decrease triglycerides and free fatty acid in mice serum. Its efficacy may associate with multiple mechanisms of action such as stimulation of insulin secretion, activation of phosphatidylinositol 3\u2010kinase\/protein kinase B, and adenosine\u2010monophosphate\u2010activated protein kinase signaling pathway, decreasing leptin.<\/jats:p>","DOI":"10.1002\/ptr.6003","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T07:24:53Z","timestamp":1513149893000},"page":"631-642","source":"Crossref","is-referenced-by-count":32,"title":["The effects of hypoglycemia and weight loss of total lignans from <i>Fructus Arctii<\/i> in KKAy mice and its mechanisms of the activity"],"prefix":"10.1002","volume":"32","author":[{"given":"Yingying","family":"Gao","sequence":"first","affiliation":[{"name":"Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenchen","family":"Gu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Drug Safety Evaluation Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefeng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-4386","authenticated-orcid":false,"given":"Zhaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.317"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"S64","article-title":"Diagnosis and classification of diabetes mellitus","volume":"35","author":"American Diabetes Association","year":"2011","journal-title":"Diabetes Care"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0452"},{"key":"e_1_2_8_5_1","first-page":"17","article-title":"Fructus Arctii is hypoglycemic and good for back and joints","volume":"30","author":"Chen Z. 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