{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:56:15Z","timestamp":1778298975603,"version":"3.51.4"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Poncirus trifoliata<\/jats:italic><\/jats:styled-content> (L.) Raf. belongs to the family Rutaceae in the genus <jats:italic>Poncirus<\/jats:italic>. Its fruits are widely used to alleviate symptoms of various disorders. The mature fruit (MF) possesses anticancer and antiinflammatory activities. Extracts of the dried, immature fruit, Poncirus fructus (PF) are widely used as a traditional medicine for ameliorating symptoms of digestive dysfunction in East Asia. Molecular and cellular mechanisms underlying the effects of MF and PF extracts on cancer, inflammation, and gastrointestinal disorders have been extensively studied in the past decade. This review summarizes recent findings on the anticancer and antiinflammatory effects of MF and the prokinetic effects of PF. Although the therapeutic effects of MF and PF have been clearly elucidated, in\u2010depth further clinical studies are still required to completely verify the clinical efficacy and safety of the fruits of <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0trifoliata<\/jats:italic><\/jats:styled-content> (L.) Raf.<\/jats:p>","DOI":"10.1002\/ptr.6008","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T05:56:55Z","timestamp":1513576615000},"page":"616-624","source":"Crossref","is-referenced-by-count":20,"title":["Phytotherapeutic effects of the fruits of <scp><i>Poncirus trifoliata<\/i><\/scp> (L.) Raf. on cancer, inflammation, and digestive dysfunction"],"prefix":"10.1002","volume":"32","author":[{"given":"Yongwoo","family":"Jang","sequence":"first","affiliation":[{"name":"McLean Hospital, Harvard Medical School  Belmont MA 02478 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Genosco  767C Concord Ave Cambridge MA 02138 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-685X","authenticated-orcid":false,"given":"Won\u2010Sik","family":"Shim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Gachon University  Incheon 21936 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.09.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00491"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.08.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12193"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042307.110802"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00453"},{"issue":"7","key":"e_1_2_8_8_1","first-page":"16","article-title":"Glucocorticoid\u2010induced osteoporosis and parathyroid hormone","volume":"33","author":"Carpinteri R.","year":"2010","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.08.088"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.09.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.11.032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4185"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3100531"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161030-00001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23274-9_15"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00460-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.03.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.55.1270"},{"issue":"2","key":"e_1_2_8_19_1","first-page":"S237","article-title":"Poncirus trifoliata Rafin. induces the apoptosis of triple\u2010negative breast cancer cells via activation of the c\u2010Jun NH(2)\u2010terminal kinase and extracellular signal\u2010regulated kinase pathways","volume":"11","author":"Han H. 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