{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:18:04Z","timestamp":1783390684580,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>The anxiolytic and antidepressant activities of the Reunion Geranium (<jats:italic>Pelargonium roseum<\/jats:italic> Willd) essential oil (EO) were evaluated in male Swiss albino mice by intraperitoneal administration of 10, 20, and 50\u00a0mg\/kg bw using elevated plus maze (EPM), open\u2010field test (OFT), and forced swimming test (FST). Moreover, we evaluated whether the 5\u2010HT<jats:sub>1A<\/jats:sub> and GABA<jats:sub>A<\/jats:sub>\u2013benzodiazepine receptor systems are involved in the anxiolytic effects through the coadministration of WAY\u2010100635 (a selective 5\u2010HT<jats:sub>1A<\/jats:sub> receptor antagonist) and flumazenil (an antagonist of benzodiazepine). GC\u2013MS revealed the monoterpene alcohols citronellol (35.9%) and geraniol (18.5%) as the main components of the <jats:italic>P.\u00a0roseum<\/jats:italic> EO. EO was effective in increasing the total number of entries and time spent in the open arms of EPM whereas number of rearing in OFT was significantly decreased in comparison with the control. In the FST, immobility time decreased in EO treated mice. Pretreatment with WAY\u2010100635, but not Flumazenil, was able to reverse the effects of the EO in the EPM and FST, indicating that the EO activity occurs via the serotonergic but not GABAergic transmission. Overall, results of this work showed significant anxiolytic and antidepressant activity of <jats:italic>P.\u00a0roseum<\/jats:italic> EO and confirmed the traditional uses of <jats:italic>Pelargonium<\/jats:italic> species as calming agents.<\/jats:p>","DOI":"10.1002\/ptr.6038","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T08:22:37Z","timestamp":1519287757000},"page":"1014-1022","source":"Crossref","is-referenced-by-count":37,"title":["Anxiolytic and antidepressant activities of <scp><i>Pelargonium roseum<\/i><\/scp> essential oil on Swiss albino mice: Possible involvement of serotonergic transmission"],"prefix":"10.1002","volume":"32","author":[{"given":"Mohaddeseh","family":"Abouhosseini Tabari","sequence":"first","affiliation":[{"name":"Department of Pharmacology Amol University of Special Modern Technologies  Amol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Hajizadeh Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-4744","authenticated-orcid":false,"given":"Filippo","family":"Maggi","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-6010","authenticated-orcid":false,"given":"Giovanni","family":"Benelli","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and Environment University of Pisa  Via del Borghetto 80 56124 Pisa Italy"},{"name":"The BioRobotics Institute Scuola Superiore Sant'Anna  Viale Rinaldo Piaggio 34 Pontedera 56025 Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1201\/b19393","volume-title":"Handbook of essential oils: Science, technology, and applications","author":"Baser K. 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