{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:41:44Z","timestamp":1788262904517,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017ZX09301029"],"award-info":[{"award-number":["2017ZX09301029"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFE0131800"],"award-info":[{"award-number":["2016YFE0131800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Depression is a common, dysthymic, and psychiatric disorder, resulting in enormous social and economic burden. Dammarane sapogenins (DS), an active fraction from oriental ginseng, has shown antidepressant\u2010like effects in chronic restraint rats and sleep interruption\u2010induced mice, and the present study aimed to further confirm the antidepressant effects of DS in a model of chronic unpredictable mild stress (CUMS) and to explore the underlying mechanism. Oral administration of DS (20, 40, and 80\u00a0mg\/kg) markedly improved depressant\u2010like behaviors, increasing the sucrose intake in the sucrose preference test and reducing the latency in the novelty\u2010suppressed feeding test, and decreasing the immobility time in both the tail suspension and forced swimming tests, compared with the CUMS mice. Biochemical analysis of brain tissue and serum showed that DS treatment restored the decreased hippocampal neurotransmitter concentrations of serotonin, dopamine, norepinephrine (noradrenaline), and gamma\u2010aminobutyric acid, and decreased the elevated of serum hormone levels (corticotrophin releasing factor, adrenocorticotrophic hormone, and corticosterone) induced by CUMS. Our findings confirm that DS exerts an antidepressant\u2010like effect in the CUMS model of depression in mice, and suggest it may be mediated by regulation of neurotransmitters and hypothalamic\u2013pituitary\u2013adrenal axis.<\/jats:p>","DOI":"10.1002\/ptr.6040","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T08:32:44Z","timestamp":1519288364000},"page":"1023-1029","source":"Crossref","is-referenced-by-count":50,"title":["Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress\u2010induced depressive mice"],"prefix":"10.1002","volume":"32","author":[{"given":"Ning","family":"Jiang","sequence":"first","affiliation":[{"name":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100006 China"},{"name":"Beijing University of Chinese Medicine  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei\u2010Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ming","family":"Dong","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Wei","family":"Lv","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Lu","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated TCM Hospital\/School of Pharmacy\/Sino\u2010Portugal TCM International Cooperation Center Southwest Medical University  Luzhou 646000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Xi","family":"Fan","sequence":"additional","affiliation":[{"name":"Affiliated TCM Hospital\/School of Pharmacy\/Sino\u2010Portugal TCM International Cooperation Center Southwest Medical University  Luzhou 646000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan university of Chinese medicine  Changsha 410208 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Le","family":"Pan","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-4645","authenticated-orcid":false,"given":"Xin\u2010Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100006 China"},{"name":"Hunan university of Chinese medicine  Changsha 410208 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"issue":"55","key":"e_1_2_7_2_1","first-page":"1","article-title":"Ginsenosides chemistry, biosynthesis, analysis, and potential health effects","volume":"55","author":"Christensen L. P.","year":"2009","journal-title":"Advances in Food and Nutrition Research"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.04.052"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00051-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.019"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"42","article-title":"Antidepressant\u2010like effect of DS\u20101226 on chronic restraint rats","volume":"21","author":"He Y.\u2010R.","year":"2013","journal-title":"Acta Laboratorium Animalis Scientia Sinica"},{"issue":"6","key":"e_1_2_7_7_1","first-page":"4","article-title":"History and evolution of the monoamine hypothesis of depression","volume":"61","author":"Hirschfeld R. M. A.","year":"2000","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7727\/wimj.2015.087"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.03.040"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.06.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20262"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.01.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.04.033"},{"key":"e_1_2_7_14_1","volume-title":"Improving effects of dammarane sapogenins on sleep interruption\u2010induced learning and memory impairment in mice","author":"Lan\u2010Lan B.","year":"2014"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"3","article-title":"The increasing burden of depression","volume":"7","author":"L\u00e9pine J. P.","year":"2011","journal-title":"Neuropsychiatric Disease & Treatment"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.050"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788168001"},{"issue":"2","key":"e_1_2_7_18_1","first-page":"173","article-title":"Efficacy and safety of add on low\u2010dose mirtazapine in depression","volume":"44","author":"Matreja P. S.","year":"2012","journal-title":"Indian Journal of Pharmacology,44,2(2012\u201303\u201016)"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.06.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5581"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.04.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.05.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/515180a"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12099"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.02.001"},{"issue":"6","key":"e_1_2_7_26_1","first-page":"737","article-title":"Antidepressant\u2010like effects and memory enhancement of a herbal formula in mice exposed to chronic mild stress","volume":"29","author":"Sun X. P.","year":"2013","journal-title":"\u79d1\u5b66\u901a\u62a5(\u82f1\u6587\u7248)"},{"issue":"26","key":"e_1_2_7_27_1","first-page":"4308","article-title":"Antidepressant\u2010like effects of total saikosaponins of Bupleurum yinchowense in mice","volume":"6","author":"Sun X.","year":"2012","journal-title":"Journal of Medicinal Plant Research"},{"issue":"2","key":"e_1_2_7_28_1","first-page":"129","article-title":"Antidepressant\u2010like effects and mechanism of action of SYG in depression model in rats","volume":"35","author":"Sun X. P.","year":"2014","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3130"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050456"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ynstr.2016.08.001","article-title":"Reliability of the chronic mild stress model of depression: A user survey","volume":"6","author":"Willner P.","year":"2016","journal-title":"Neurobiology of Stress"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187257"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2016.09.023","volume-title":"Antidepressant\u2010like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina baroni in chronic unpredictable mild stress rats and its related mechanism","author":"Xu P","year":"2016"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.010369"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.2001.890203.x"},{"key":"e_1_2_7_36_1","article-title":"Antidepressant effects of DS-1226 on mouse models of depression induced by chronic sleep interruption","author":"Zhang B. Y.","year":"2017","journal-title":"Acta Laboratorium Animalis Scientia Sinica"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:34:32Z","timestamp":1695483272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/ptr.6040"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6040","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,22]]}}}