{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:28:33Z","timestamp":1767997713894,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Korean red pine (<jats:italic>Pinus densiflora<\/jats:italic>) bark has been traditionally used in Korea and other parts of East Asia to relieve inflammatory diseases. Although many studies using <jats:italic>P.\u00a0densiflora<\/jats:italic> bark have been reported, its effect on atopic dermatitis (AD) has not been elucidated. Thus, we investigated whether the <jats:italic>P.\u00a0densiflora<\/jats:italic> bark extract (PBE) has potential to attenuate AD symptoms and elucidated the molecular mechanism. Oral administration of PBE to mice with 2,4\u2010dinitrochlorobenzene (DNCB)\u2010induced AD lessened dermatitis scores and scratching behavior and significantly reduced measures of epidermal thickness, infiltration of mast cells and eosinophils, levels of immunoglobulin E (IgE), and IgG<jats:sub>1<\/jats:sub>\/IgG<jats:sub>2a<\/jats:sub> ratio in serum. PBE not only inhibited IL\u20104, IL\u20105, and IL\u201013 but also increased IFN\u2010\u03b3 in splenic production. Furthermore, PBE significantly suppressed mRNA expression of thymic stromal lymphopoietin and further downregulated the mRNA expression of Th2 and Th17 cytokines such as IL\u20104, IL\u201013, IL\u201017, IL\u201031, and TNF\u2010\u03b1. In addition, the protein expressions of filaggrin, involucrin, and loricrin in lesional skin were recovered by PBE. These results suggest that PBE attenuates DNCB\u2010induced AD via regulating Th1\/Th2 balance and skin barrier function.<\/jats:p>","DOI":"10.1002\/ptr.6061","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T06:38:47Z","timestamp":1519713527000},"page":"1135-1143","source":"Crossref","is-referenced-by-count":26,"title":["<i>Pinus densiflora<\/i> bark extract ameliorates 2,4\u2010dinitrochlorobenzene\u2010induced atopic dermatitis in NC\/Nga mice by regulating Th1\/Th2 balance and skin barrier function"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-3386","authenticated-orcid":false,"given":"Jun Woo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Graduate School Kyung Hee University  26, Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-3457","authenticated-orcid":false,"given":"Qianwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Graduate School Kyung Hee University  26, Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-9228","authenticated-orcid":false,"given":"Young Pyo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Graduate School Kyung Hee University  26, Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 Republic of Korea"},{"name":"Department of Oriental Pharmaceutical Science, College of Pharmacy Kyung Hee University  26, Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-6263","authenticated-orcid":false,"given":"Se Young","family":"Choung","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Graduate School Kyung Hee University  26, Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 Republic of Korea"},{"name":"Department of Preventive Pharmacy and Toxicology, College of Pharmacy Kyung Hee University  26, Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1612.12037"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12222"},{"key":"e_1_2_6_4_1","volume-title":"The medicinal plants of Korea","author":"Bae K.","year":"2000"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000110"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.05.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-013-0013-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.03.045"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2812"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.141"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00766.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01412.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.047"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.031"},{"issue":"3","key":"e_1_2_6_17_1","first-page":"246","article-title":"Quantitative analysis of Taxifolin, (+)\u2010Catechin and Procyanidin B1 from the preparation of Pinus densiflora (PineXol\u00ae)","volume":"47","author":"Hwang Y. 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