{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:32:43Z","timestamp":1788571963078,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Graduate Education Innovation Project of Guangdong Province","award":["2015QTLXXM37"],"award-info":[{"award-number":["2015QTLXXM37"]}]},{"name":"team item of Natural Science Foundation of Guangdong Province","award":["2016A030313808"],"award-info":[{"award-number":["2016A030313808"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Postpartum dysgalactia is a common clinical problem for lactating women. Seeking out the safe and efficient phytoestrogens will be a promising strategy for postpartum dysgalactia therapy. In this study, the postpartum mice within four groups, including control group, the model group, and the treatment groups intragastrically administrated with normal saline, bromocriptine, bromocriptine plus 17\u03b1\u2010ethinyl estradiol, and bromocriptine plus quercetin, respectively, were used. The results showed that quercetin, a kind of natural phytoestrogen, could efficiently promote lactation yield and mammary gland development in the agalactosis mice produced by bromocriptine administration. Mechanically, quercetin, such as 17\u03b1\u2010ethinyl estradiol, significantly stimulated prolactin (PRL) production and deposition in the mammary gland in the agalactosis mice determined by western blotting, quantitative polymerase chain reaction, and enzyme\u2010linked immunosorbent assay, respectively. Furthermore, quercetin could increase the expression of \u03b2\u2010casein, stearoyl\u2010CoA desaturase, fatty acid synthase, and \u03b1\u2010lactalbumin in the breast tissues that are responsible for the production of fatty acid, lactose, and galactose in the milk at the transcriptional level determined by quantitative polymerase chain reaction. Specifically, quercetin promoted primary mammary epithelial cell proliferation and stimulated prolactin receptor (PRLR) expression probably via AKT activation in vitro. In conclusion, this study indicates that estrogen\u2010like quercetin promotes mammary gland development and lactation yield in milk\u2010deficient mice, probably via stimulating PRL expression and release from the pituitary gland, as well as induces PRLR expression in primary mammary epithelial cells.<\/jats:p>","DOI":"10.1002\/ptr.6079","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T15:11:12Z","timestamp":1524150672000},"page":"1511-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Quercetin improves postpartum hypogalactia in milk\u2010deficient mice via stimulating prolactin production in pituitary gland"],"prefix":"10.1002","volume":"32","author":[{"given":"Man","family":"Lin","sequence":"first","affiliation":[{"name":"School of Nursing Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of gynecology the Eleventh People's Hospital of Guangzhou  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Nursing Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nursing Guangzhou Women and Children Medical Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-3809","authenticated-orcid":false,"given":"Tianhui","family":"You","sequence":"additional","affiliation":[{"name":"School of Nursing Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangzhou key laboratory of construction and application of new drug screening model systems Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1653"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2850469"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.02.005"},{"issue":"4","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5604\/00306657.1199345","article-title":"The influence of the body mass index (BMI) on selected parameters of the coagulation system in patients with disorders of the balance system taking oral contraceptives","volume":"70","author":"Bieli\u0144ska M.","year":"2016","journal-title":"Polish Journal of Otolaryngologia."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(99)00062-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2007.01649.x"},{"issue":"10","key":"e_1_2_7_9_1","first-page":"547","article-title":"Nutrition for healthy term infants, six to 24 months: An overview","volume":"19","author":"Critch J. 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