{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:02:27Z","timestamp":1791896547219,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Three different extracts of<jats:styled-content style=\"fixed-case\"><jats:italic>Matricaria chamomilla<\/jats:italic><\/jats:styled-content>L. were evaluated for their antihypertensive activity, these extracts were total alcohol extract (Extract 1), oil extracted (Extract 2), and water lifted after oil extraction (Extract 3). Quantitative and Qualitative analyses were carried out for all extracts. The 3 extracts were proved to be safe for human use. A single oral administration of the plant extracts (200\u00a0mg\/kg) decreases both systolic and diastolic blood pressure of normotensive rats after 1, 1.5, and 2\u00a0hr. Furthermore, groups treated with the evaluated extracts (100 &amp; 200\u00a0mg\/kg) or Captopril (20\u00a0mg\/kg) showed a significant reduction in the elevated blood pressure and heart rate. Extract 3 showed the most antihypertensive activity. Serum biochemical parameters and lipid profile levels of treated groups were improved in comparison with induced\u2010hypertensive untreated rats. In evaluation of oxidative damage parameters Glutathione and superoxide dismutase (<jats:bold>SOD<\/jats:bold>) in some organs, the investigated extracts or captopril restored the amount of reduced Glutathione in tissues in addition to an increase in the activity of the SOD after a significant depletion of SOD activity. In the clinical study, there was a significant dose dependent decrease in Systolic blood pressure, Diastolic blood pressure, and heart rate compared with their basal values in both normotensive and hypertensive human volunteers after oral administration of<jats:styled-content style=\"fixed-case\"><jats:italic>Matricaria chamomilla<\/jats:italic><\/jats:styled-content>beverages.<\/jats:p>","DOI":"10.1002\/ptr.6086","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T22:43:44Z","timestamp":1523832224000},"page":"1564-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Experimental and clinical antihypertensive activity of<scp><i>Matricaria chamomilla<\/i><\/scp>extracts and their angiotensin\u2010converting enzyme inhibitory activity"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-6841","authenticated-orcid":false,"given":"Amani A.","family":"Awaad","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, College of Pharmacy Prince Sattam bin Abdulaziz University Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham M.","family":"El\u2010Meligy","sequence":"additional","affiliation":[{"name":"Aromatic and Medicinal Plants Department, Desert Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Zain","sequence":"additional","affiliation":[{"name":"School of pharmacy and Medical Sciences, Faculty of Life Sciences University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"Safhi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Prince Sattam Bin Abdul Aziz University Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura A.","family":"AL Qurain","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Prince Sattam Bin Abdul Aziz University Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekhah S.","family":"Almoqren","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Prince Sattam Bin Abdul Aziz University Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara M.","family":"Zain","sequence":"additional","affiliation":[{"name":"School of pharmacy and Medical Sciences, Faculty of Life Sciences University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya D.","family":"Sesh Adri","sequence":"additional","affiliation":[{"name":"Pharmacology Department, College of Pharmacy Prince Sattam bin Abdulaziz University Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad I.","family":"Al\u2010Saikhan","sequence":"additional","affiliation":[{"name":"Clinical pharmacy Department, College of Pharmacy Prince Sattam Bin Abdulaziz University Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2008.11.036"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01355-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01167564"},{"key":"e_1_2_8_5_1","first-page":"483","volume-title":"Textbook of Therapeutics\u2010Drug and Disease Management","author":"Akinyeye Berardi R. 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