{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:04:35Z","timestamp":1787321075325,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 27814\u2010B22"],"award-info":[{"award-number":["P 27814\u2010B22"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n                    The antileishmanial activity of the essential oil (EO) from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Chenopodium ambrosioides<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major EO compounds carvacrol, caryophyllene oxide (Caryo), and the antileishmanial endoperoxide ascaridole (Asc) on mitochondrial functions in\n                    <jats:italic>Leishmania tarentolae<\/jats:italic>\n                    promastigotes (LtP). EO and Caryo were able to partially inhibit the leishmanial electron transport chain, whereas other components failed to demonstrate a direct immediate effect. Caryo demonstrated inhibition of complex III activity in LtP and in isolated complex III from other species. The formation of superoxide radicals was studied in\n                    <jats:italic>Leishmania<\/jats:italic>\n                    by electron spin resonance spectroscopy in the presence of iron chelators wherein selected compounds failed to trigger a significant immediate additional superoxide production in LtP. However, upon prolonged incubation of\n                    <jats:italic>Leishmania<\/jats:italic>\n                    with Asc and especially in the absence of iron chelators (allowing the activation of Asc), an increased superoxide radical production and significant impairment of mitochondrial coupling in\n                    <jats:italic>Leishmania<\/jats:italic>\n                    was observed. Prolonged incubation with all EO components resulted in thiol depletion. Taken together, the major components of EO mediate their leishmanicidal activity via different mitochondrial targets and time profiles. Further studies are required to elucidate possible synergistic effects of carvacrol and Asc and the influence of minor compounds.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6097","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T13:46:17Z","timestamp":1524145577000},"page":"1729-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of\n                    <i>Chenopodium ambrosioides<\/i>\n                    L. with mitochondria in\n                    <i>Leishmania<\/i>\n                    and other eukaryotes"],"prefix":"10.1002","volume":"32","author":[{"given":"Lianet","family":"Monzote","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Department of Biomedical Sciences University of Veterinary Medicine Vienna Vienna Austria"},{"name":"Department of Parasitology Institute of Tropical Medicine \u201cPedro Kour\u00ed\u201d Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Geroldinger","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Department of Biomedical Sciences University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Tonner","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Department of Biomedical Sciences University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Scull","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Pharmacy and Food Havana University Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sritama","family":"De Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Postgraduate Medical Education &amp; Research Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Department of Biomedical Sciences University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bacher","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division of Chemistry of Renewables University of Natural Resources and Life Sciences Tulln Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Staniek","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Department of Biomedical Sciences University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitali","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Postgraduate Medical Education &amp; Research Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rosenau","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division of Chemistry of Renewables University of Natural Resources and Life Sciences Tulln Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-0201","authenticated-orcid":false,"given":"Lars","family":"Gille","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Department of Biomedical Sciences University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00790-10"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.761"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.1.4.655"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00157"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2112"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1016\/S0021-9258(18)33617-2","article-title":"Import of proteins into mitochondria. 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