{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:06:08Z","timestamp":1789095968871,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Prof. Tae-Hoo Yi"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Paeonia suffruticosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)\u2010induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB\u2010induced phosphorylation of mitogen\u2010activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase\u20101 expression, confirmed by greater nuclear accumulation of nuclear factor E2\u2010releated factor 2 (Nrf2). Furthermore, this study proved that the endogenous antioxidant system Nrf2\/antioxidant response element was regulated by dihydrolipoamide dehydrogenase, a tricarboxylic acid (TCA) cycle\u2010associated protein whose level was decreased after UVB exposure. PS and PA promoted the production of dihydrolipoamide dehydrogenase, as well as the activation of Nrf2 and antioxidant response element, resulting in preventing procollagen type I ruined caused by UVB. In vivo, topical application of PS and PA attenuated UVB\u2010induced matrix metalloproteinase\u20101 production and promoted procollagen type I in hairless mice. These results suggested PA a promising botanical in protecting skin from UVB\u2010induced photoaging.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6100","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T01:30:14Z","timestamp":1526002214000},"page":"1741-1749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Paeonol extracted from\n                    <i>Paeonia suffruticosa<\/i>\n                    Andr. ameliorated UVB\u2010induced skin photoaging via DLD\/Nrf2\/ARE and MAPK\/AP\u20101 pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"ZhengWang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Oriental Medicinal Material and Processing, College of Life Sciences Kyung Hee University  1732, Deogyeong\u2010daero, Giheung\u2010gu Yongin\u2010si Gyeonggi\u2010do 17104 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, Henan Province Collaborative Innovation Center for Food Production and Safety Zhengzhou University of Light Industry  166 Kexue Ave Zhengzhou Henan Sheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunson","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicinal Material and Processing, College of Life Sciences Kyung Hee University  1732, Deogyeong\u2010daero, Giheung\u2010gu Yongin\u2010si Gyeonggi\u2010do 17104 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-6542","authenticated-orcid":false,"given":"Tae\u2010Hoo","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.01.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00019.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/379335a0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.08.021"},{"key":"e_1_2_9_7_1","first-page":"275","article-title":"Circumscription of Paeonia suffruticosa Andrews and identification of cultivated tree peonies","volume":"42","author":"Hong D. Y.","year":"2004","journal-title":"Acta Phytotaxonomica Sinica"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5198"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(01)00425-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-381"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.01063.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b00467"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b12-00977"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2006.01.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.01.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-011-9500-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23693"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00329.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/651890","article-title":"Paeonol attenuates cigarette smoke\u2010induced lung inflammation by inhibiting ROS\u2010sensitive inflammatory signaling","volume":"2014","author":"Liu M. H.","year":"2014","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_9_20_1","first-page":"5061","article-title":"Paeonia lactiflora Pall. protects against ANIT\u2010induced cholestasis by activating Nrf2 via PI3K\/Akt signaling pathway","volume":"9","author":"Ma X.","year":"2015","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.12.016"},{"key":"e_1_2_9_22_1","first-page":"337","article-title":"Lipoic acid as an antioxidant. The role of dihydrolipoamide dehydrogenase","volume":"108","author":"Patel M. S.","year":"1998","journal-title":"Methods in Molecular Biology Clifton (NJ)"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010835200"},{"key":"e_1_2_9_24_1","first-page":"397","article-title":"The multienzyme alpha\u2010keto acid dehydrogenase complexes","volume":"21","author":"Reed L. J.","year":"1968","journal-title":"Brookhaven Symposia in Biology"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2173275"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469048"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900240"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12427"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1764"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00902.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.descs.2005.06.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530600971974"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1435"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:03:00Z","timestamp":1694847780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,10]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/ptr.6100"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6100","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,10]]},"assertion":[{"value":"2018-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}