{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:16:10Z","timestamp":1788383770645,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Basic Research Program of Higher Education of Liaoning Province of China","award":["LQ2017027"],"award-info":[{"award-number":["LQ2017027"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Costunolide, a sesquiterpene lactone, is a small molecular monomer extracted from <jats:styled-content style=\"fixed-case\"><jats:italic>Inula helenium<\/jats:italic><\/jats:styled-content> (Compositae). In the present study, we assessed the antileukemia effects of costunolide on the human chronic myeloid leukemia cell line K562 and its combined activity with imatinib. A Cell Counting Kit\u20108 assay demonstrated that costunolide significantly inhibited K562 cell proliferation and enhanced imatinib\u2010induced anti\u2010proliferative activity. We found that costunolide significantly induced mitochondrial apoptosis in K562 cells by modulating the protein levels of Bcl\u20102 family members and by inducing caspase activation. Costunolide promoted imatinib\u2010induced apoptosis via the Bcr\/Abl\u2013signal transducer and activator of transcription 5 pathway. Costunolide inhibited proliferation by inducing cell cycle arrest in the G<jats:sub>2<\/jats:sub>\/M phase by decreasing cyclin B1 and cyclin\u2010dependent kinase 2 expression and increasing p21 expression. Together, these results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia.<\/jats:p>","DOI":"10.1002\/ptr.6106","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T10:42:15Z","timestamp":1524825735000},"page":"1764-1769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Costunolide promotes imatinib\u2010induced apoptosis in chronic myeloid leukemia cells via the Bcr\/Abl\u2013Stat5 pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Hong","family":"Cai","sequence":"first","affiliation":[{"name":"Clinical Laboratory The Second Hospital of Dalian Medical University  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Laboratory The Second Hospital of Dalian Medical University  Dalian 116023 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