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A systematic literature search was performed in the PubMed, Scopus, Web of Science, Google Scholar, and other databases using VaD, and medicinal plants as key terms. No strict inclusion criteria were defined, and almost all clinical studies were included. A total of 524 articles were found, of which only 28 relevant articles with 3461 studied patients were included to this systematic review. The results showed that medicinal plants, particularly <jats:italic>Sancaijiangtang<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>Ginkgo biloba<\/jats:italic><\/jats:styled-content> could improve behavioral and psychological symptoms, working memory, Mini\u2010Mental State Examination, and activities of daily living as well as neuropsychiatric features. It was also shown that the age, average progression of the disease, and the type of folk medicines effective in treating the disease are important factors in the management of VaD. The results of this review indicated that herbal therapy can be a potential candidate in the treatment of VaD; however, further studies are needed to confirm such efficiency.<\/jats:p>","DOI":"10.1002\/ptr.6120","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T09:05:45Z","timestamp":1526979945000},"page":"1720-1728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-4619","authenticated-orcid":false,"given":"Adel","family":"Ghorani\u2010Azam","sequence":"first","affiliation":[{"name":"Medical Toxicology Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Sepahi","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Khodaverdi","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of pharmaceutics, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-9625","authenticated-orcid":false,"given":"Seyed Ahmad","family":"Mohajeri","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400024q"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.7.863"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2009.01133.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.02.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2005.01.1563"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"Bowen M. 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