{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:34:30Z","timestamp":1790141670804,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran","award":["Grant"],"award-info":[{"award-number":["Grant"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cinnamomum zeylanicum<\/jats:italic>\n                    <\/jats:styled-content>\n                    (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia\u2010induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague\u2013Dawley rats were subjected to 30\u00a0min of ischemia by occlusion of the left anterior descending coronary artery followed by 5\u00a0days of reperfusion. Thirty\u2010two animals were randomized to receive daily oral administration of vehicle or\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u00a0zeylanicum<\/jats:italic>\n                    <\/jats:styled-content>\n                    bark extract (intragastric, 50, 100, or 200\u00a0mg\/kg) 14\u00a0days before ischemia.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u00a0zeylanicum<\/jats:italic>\n                    <\/jats:styled-content>\n                    was standardized through HPLC analysis. Administration of cinnamon bark extract significantly improved ischemia\/reperfusion\u2010induced myocardial injury as evidenced by reduction of the infarct size. Also, during the ischemic period, ventricular tachycardia and ventricular ectopic beats episodes decreased as compared with that of the control group. The extract stabilized the ST segment changes and QTc shortening, decreased R\u2010wave amplitude, and increased heart rate during ischemia. The extract also caused significant elevations in serum superoxide dismutase and glutation proxidase activities as well as a significant decrease in serum cardiac troponin I, lactate dehydrogenase, and malondialdehyde levels, 5\u00a0days after reperfusion. In HPLC analysis, the amounts of Cinamic acid, Methyl eugenol, and Cinnamaldehyde were 8.99\u00a0\u00b1\u00a00.5, 13.02\u00a0\u00b1\u00a01.8, and 14.63\u00a0\u00b1\u00a01.1\u00a0mg\/g, respectively. The results show that the ethanolic extract of cinnamon bark is able to protect the heart against ischemia\u2013reperfusion injury probably due to its antioxidant properties. Hence, it might be beneficial in these patients and this remedy might be used for preparation of new drugs.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6127","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T10:02:49Z","timestamp":1529402569000},"page":"1983-1991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Protective effects of cinnamon bark extract against ischemia\u2013reperfusion injury and arrhythmias in rat"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-2413","authenticated-orcid":false,"given":"Mehrnoosh","family":"Sedighi","sequence":"first","affiliation":[{"name":"Razi Herbal Medicines Research Center Lorestan University of Medical Sciences  Khorramabad Iran"},{"name":"Student Research Committee Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Nazari","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center and Department of Physiology Lorestan University of Medical Science  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Tehran University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Rafieian\u2010Kopaei","sequence":"additional","affiliation":[{"name":"Medical Plants Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Anesthesiologist, Faculty of Medicine Lorestan University of Medical Science  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Moghimian","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Gonabad University of Medical Science  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ali","family":"Mozaffarpur","sequence":"additional","affiliation":[{"name":"Traditional Medicine and History of Medical Sciences Research Center, Institute of Health Babol University of Medical Science  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Rashidipour","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Namdari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Cheraghi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Rasoulian","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center and Department of Physiology Lorestan University of Medical Science  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.12.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90182-V"},{"key":"e_1_2_9_4_1","first-page":"353","article-title":"An analysis of the time relations of electrocardiograms","volume":"7","author":"Bazett H. 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