{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:23:45Z","timestamp":1790141025479,"version":"4.0.1"},"reference-count":203,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T00:00:00Z","timestamp":1531612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)\u2010induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP\u2010induced myocardial ischemia including coriander, curcumin,\n                    <jats:italic>Momordica<\/jats:italic>\n                    , quercetin, and\n                    <jats:italic>Withania somnifera<\/jats:italic>\n                    . These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NF\u043aB, p\u201021 activated kinase 1 (PAK1), and p\u2010smad2\/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP\u2010induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant\u2010based interventions screened for cardioprotective effect in ISP\u2010induced cardiotoxicity, and their probable mechanistic profile is summarized.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6152","type":"journal-article","created":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T23:44:12Z","timestamp":1531698252000},"page":"1908-1932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Isoproterenol\u2010induced cardiac ischemia and fibrosis: Plant\u2010based approaches for intervention"],"prefix":"10.1002","volume":"32","author":[{"given":"Prince","family":"Allawadhi","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmaceutical Education and Research (SPER), Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Regulatory Toxicology National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad Telangana State India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilofer","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Regulatory Toxicology National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad Telangana State India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Regulatory Toxicology National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad Telangana State India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5904-3134","authenticated-orcid":false,"given":"Chandraiah","family":"Godugu","sequence":"additional","affiliation":[{"name":"Department of Regulatory Toxicology National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad Telangana State India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-016-0494-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2013-0139"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"739","article-title":"Tomato lycopene and its role in human health and chronic diseases","volume":"163","author":"Agarwal S.","year":"2000","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_9_5_1","first-page":"137","volume-title":"Sustained energy for enhanced human functions and activity","author":"Ahmad M.","year":"2018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-011-0558-2"},{"issue":"18","key":"e_1_2_9_7_1","first-page":"3445","article-title":"Morin, a flavonoid, prevents lysosomal damage in experimental myocardial ischemic rats","volume":"6","author":"Al\u2010Numair K. 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