{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:31:03Z","timestamp":1785389463945,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>The beneficial effects of isothiocyanate\u2010based compounds, as well as their safety, have been shown in neuropathological disorders, such as neuropathic pain. Aim of the present work was to study the efficacy of the glucosinolate glucoraphanin (GRA) and the derived isothiocyanate sulforaphane (SFN), secondary metabolites occurring exclusively in <jats:italic>Brassicales<\/jats:italic>, on chemotherapy\u2010induced neuropathic pain. Mice were repeatedly treated with oxaliplatin (2.4\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> ip) for 14\u00a0days to induce neuropathic pain. GRA and SFN effects were evaluated after a single administration on Day 15 or after a daily repeated oral and subcutaneous treatment starting from the first day of oxaliplatin injection until the 14<jats:sup>th<\/jats:sup> day. Single subcutaneous and oral administrations of GRA (4.43\u2013119.79\u00a0\u03bcmol\u00a0kg<jats:sup>\u22121<\/jats:sup>) or SFN (1.33\u201313.31\u00a0\u03bcmol\u00a0kg<jats:sup>\u22121<\/jats:sup>) reduced neuropathic pain in a dose\u2010dependent manner. The repeated administration of GRA and SFN (respectively 13.31 and 4.43\u00a0\u03bcmol\u00a0kg<jats:sup>\u22121<\/jats:sup>) prevented the chemotherapy\u2010induced neuropathy. The co\u2010administration of GRA and SFN in mixture with the H<jats:sub>2<\/jats:sub>S binding molecule, haemoglobin, abolished their pain\u2010relieving effect, which was also reverted by pretreating the animals with the selective blocker of Kv7 potassium channels, XE991. GRA and SFN reduce neuropathic pain by releasing H<jats:sub>2<\/jats:sub>S and modulating Kv7 channels and show a protective effect on the chemotherapy\u2010induced neuropathy.<\/jats:p>","DOI":"10.1002\/ptr.6159","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:21:43Z","timestamp":1533306103000},"page":"2226-2234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Effect of glucoraphanin and sulforaphane against chemotherapy\u2010induced neuropathic pain: Kv7 potassium channels modulation by H<sub>2<\/sub>S release <i>in vivo<\/i>"],"prefix":"10.1002","volume":"32","author":[{"given":"Elena","family":"Lucarini","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health\u2013Neurofarba\u2013Pharmacology and Toxicology Section University of Florence  Florence 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