{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:03:45Z","timestamp":1790219025103,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200540"],"award-info":[{"award-number":["81200540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Hepatic ischemia\/reperfusion (I\/R) injury is a major cause of high morbidity and mortality after liver resection, transplantation, and hemorrhagic shock. Paeoniflorin (PF), the main substance of glucosides in <jats:italic>Radix Paeoniae Alba<\/jats:italic>, has been widely used to treat various hepatic inflammatory diseases including I\/R injury. However, the underlying mechanisms of PF on hepatic I\/R injury remain further investigated. In this study, the liver I\/R model was performed by clamping the portal vein and hepatic artery with an atraumatic clamp for 90\u00a0min followed by 6\u00a0hr reperfusion. PF (100\u00a0mg\/kg) was given three times a day by gavage before I\/R. The blood and hepatic samples were collected to evaluate liver injury and molecular indexes. The results showed that PF pretreatment significantly inhibited I\/R\u2010induced serum ALT and AST activities (40.3% and 53.8% those of I\/R group, respectively), hepatic pathological damages and hepatic apoptosis (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.01), and infiltration of neutrophils into liver. In addition, PF suppressed the production of pro\u2010inflammatory cytokines (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.01), decreased the expression of high mobility group box\u20101 (HMGB1), and down\u2010regulated toll\u2010like receptors 4 (TLR4) and phosphorylated ERK1\/2, JNK1\/2, p38, and NF\u2010\u03baB signal molecules expression in the I\/R\u2010operated mice. These findings indicated that PF played a protective role in liver I\/R injury, and this protection was associated with inhibition of I\/R\u2010activated HMGB1\u2010TLR4 signaling pathway to attenuate hepatic inflammation responses.<\/jats:p>","DOI":"10.1002\/ptr.6161","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T09:31:08Z","timestamp":1532597468000},"page":"2247-2255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Paeoniflorin protects against liver ischemia\/reperfusion injury in mice via inhibiting HMGB1\u2010TLR4 signaling pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Tianjun","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Anatomy Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell and Tissue Engineering Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Huang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiahong","family":"Chen","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Tie","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anatomy Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-6474","authenticated-orcid":false,"given":"Jingyuan","family":"Wan","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5858"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.04.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.11.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5575"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5868"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"270","article-title":"Role of toll\u2010like receptors in liver transplantation. 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