{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:59:19Z","timestamp":1791917959357,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p><jats:italic>Panax notoginseng<\/jats:italic> is a well\u2010known traditional Chinese medicine, and dried flower buds of <jats:italic>P. notoginseng<\/jats:italic> (FBP) have also been used as a medicine or tea for a long time. The pharmacological effects of FBP include antihypertensive, anticancer, hepatoprotective, and cardiovascular protective effects. The compounds in FBP include saponins, flavonoids, volatile oils, and polysaccharides. The total saponins are the principal bioactive components. In modern applications, FBP is used to treat hypertension and tinnitus. There have been many studies on FBP and its effects in recent years, and it has attracted much attention in the medical field. This review summarizes the chemical components, pharmacological action, and clinical uses of FBP comprehensively to provide the references of deeper studies.<\/jats:p>","DOI":"10.1002\/ptr.6167","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T08:04:07Z","timestamp":1533715447000},"page":"2155-2163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Phytochemistry, pharmacology, and clinical use of <i>Panax notoginseng<\/i> flowers buds"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-6358","authenticated-orcid":false,"given":"Siqi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxi","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1314","article-title":"Effect study on blood pressure by Panax notoginseng flower saponins","volume":"27","author":"Cao M.","year":"2012","journal-title":"Guang Ming Zhong Yi"},{"key":"e_1_2_8_3_1","first-page":"47","article-title":"Flos Notoginseng's antihypertensive effect and its influence on plasma t\u2010PA, PAI and vWF","volume":"46","author":"Cao M.","year":"2012","journal-title":"Shanghai Journal of Traditional Chinese Medicine"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.05.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009972"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-53"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6542"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-5-38"},{"key":"e_1_2_8_9_1","first-page":"1810","article-title":"Determination of effective components in different positions of Panax notoginseng by HPLC","volume":"32","author":"Cui H. 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