{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:05:01Z","timestamp":1791828301232,"version":"4.3.4"},"reference-count":281,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    <jats:italic>Vitis vinifera<\/jats:italic>\n                    (grape) is one of the \u201cmost\u2010produced fruit\u201d in the world. Grape seeds are a valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its biologically active constituents, RSV, exert their protective effects against different natural or chemical toxins which could alter physiological homeostasis through a variety of mechanisms. Some of these mechanisms of actions include increase in superoxide dismutase, hemeoxygenase\u20101, and glutathione peroxidase activities and reduced glutathione content and decrease in malondialdehyde (MDA) levels and activation of the nuclear erythroid2\u2010related factor2\/ARE pathway. There are also various reports of the potential use of such compounds in preventing different ailments including cardiovascular diseases, cancer, degenerative diseases, and inflammatory disorders. Therefore, in this review, we have investigated the possible protective effects of grape and one of its biologically active constituents, RSV, on different organs' toxicity induced by natural toxins (such as mycotoxins, lipopolysaccharide, and triptolide) and chemical toxins (such as antitumors, metals, and carbon tetrachloride). There are insufficient clinical trials on this subject, so our review only includes in vivo and in vitro studies. To establish the grape beneficial effects in human intoxication, more clinical trials need to be accomplished.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6168","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T04:18:52Z","timestamp":1533701932000},"page":"2164-2190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Protective effects of\n                    <scp>\n                      <i>Vitis vinifera<\/i>\n                    <\/scp>\n                    (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities:\n                    <scp>A<\/scp>\n                    comprehensive review"],"prefix":"10.1002","volume":"32","author":[{"given":"Jamshid","family":"Tabeshpour","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soghra","family":"Mehri","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Neurocognitive Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Shaebani Behbahani","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-851X","authenticated-orcid":false,"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.02.003"},{"issue":"12","key":"e_1_2_7_3_1","first-page":"4787","article-title":"Grape seed extracted (vitis vinifera) alleviate hepatic toxicity induced by the anti\u2010oestrogen tamoxifen in female albino rats","volume":"7","author":"Abd\u2010Ella E. M. M.","year":"2016","journal-title":"International Journal of Pharmaceutical Sciences Review and Research"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"38","article-title":"Protective effect of grape seeds proanthocyanidins against naphthalene\u2010induced hepatotoxicity in rats","volume":"15","author":"Ahmed A. A.","year":"2007","journal-title":"Saudi Pharmaceutical Journal"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5570"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134768"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2384"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4928"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.729065"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.12.035"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"741018","article-title":"Side effects of radiographic contrast media: Pathogenesis, risk factors, and prevention","volume":"2014","author":"Andreucci M.","year":"2014","journal-title":"BioMed Research International"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.05.011"},{"issue":"6","key":"e_1_2_7_13_1","first-page":"698628","article-title":"Effect of resveratrol on hematological and biochemical alterations in rats exposed to fluoride","volume":"2014","author":"Atmaca N. Y. E.","year":"2014","journal-title":"BioMed Research International"},{"issue":"2","key":"e_1_2_7_14_1","first-page":"120","article-title":"The effects of oral grape seed extract on cisplatin\u2010induced cytogenotoxicity in mice","volume":"16","author":"Attia S. M.","year":"2008","journal-title":"Saudi Pharmaceutical Journal"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.05.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.04.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.76"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703626"},{"issue":"3","key":"e_1_2_7_19_1","first-page":"321","article-title":"Effects of long\u2010term use of fluoxetine on fertility parameters in adult male rats","volume":"28","author":"Bataineh H. N.","year":"2007","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1636-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2011.10.002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.11.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00139-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052164"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.05.005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2907"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1253"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4tx00007b"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2003.10.057"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867013373048"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-003-0538-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR1190.1"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5505\/tjb.2015.22448"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4999\/uhod.10060"},{"issue":"2","key":"e_1_2_7_35_1","first-page":"92","article-title":"The effect of grape seed extract on radiation\u2010induced oxidative stress in the rat liver","volume":"19","author":"Cetin A.","year":"2008","journal-title":"The Turkish Journal of Gastroenterology"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08006302"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1103"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.10.019"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12084991"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.01.011"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060654"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.02.004"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.21919"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.05.030"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400819"},{"issue":"4","key":"e_1_2_7_46_1","first-page":"217","article-title":"Fluoride and oxidative stress","volume":"36","author":"Chlubek D.","year":"2003","journal-title":"Fluoride"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.11.018"},{"issue":"18","key":"e_1_2_7_48_1","first-page":"1731","article-title":"The toxicology of mercury\u2014Current exposures and clinical manifestations","volume":"349","author":"Clarkson T. W.","year":"2003","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0566-z"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.11.011"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200060040-00005"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200304001-00004"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23453"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.2834"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327112468178"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2014.881944"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.06.032"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1569452"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.129"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28692"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713498437"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1950-9"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2016.4.13611"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7010097"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.04.014"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.06.068"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820130600745927"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.06.011"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-012-9592-0"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR11.927"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5709"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.pto_497.x"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3200"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7835.2007.00125.x"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2013-097"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3368"},{"issue":"5","key":"e_1_2_7_77_1","first-page":"377","article-title":"Investigation on the protective effect of grape seed and Linseed oils against ciclophosphamide induced genotoxicity in mice","volume":"3","author":"El\u2010Rahim A.","year":"2009","journal-title":"Global Veterinaria"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12205"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632016651447"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2009.05.013"},{"issue":"3","key":"e_1_2_7_81_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.866717","article-title":"Identification of the mutagens in cooked beef","volume":"67","author":"Felton J. S.","year":"1986","journal-title":"Environmental Health Perspectives"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059888"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.03.031"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00179-6"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-12"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.06.002"},{"issue":"1","key":"e_1_2_7_87_1","first-page":"151","article-title":"Resveratrol attenuates azidothymidine\u2010induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes","volume":"4","author":"Gao R. Y.","year":"2011","journal-title":"Molecular Medicine Reports"},{"issue":"3","key":"e_1_2_7_88_1","first-page":"57","article-title":"Cellular mechanisms of lead neurotoxicity","volume":"12","author":"Garza A.","year":"2006","journal-title":"Medical Science Monitor"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.11.011"},{"issue":"6","key":"e_1_2_7_90_1","first-page":"973134","article-title":"Specific conditions for resveratrol neuroprotection against ethanol\u2010induced toxicity","volume":"2012","author":"Gonthier B.","year":"2012","journal-title":"Journal of Toxicology"},{"issue":"8","key":"e_1_2_7_91_1","first-page":"1811","article-title":"Aminoglycosides: A practical review","volume":"58","author":"Gonzalez L. S.","year":"1998","journal-title":"American Family Physician"},{"key":"e_1_2_7_92_1","doi-asserted-by":"crossref","unstructured":"Granato D.(2016).Reflectance of botanical production and geographical origin on the unique compositional traits of purple grape juices. Wageningen University. DOI: 10.18174\/388693.","DOI":"10.18174\/388693"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021565"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016310791162767"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1174-1"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2858129"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.17795\/jjnpp-27512"},{"issue":"3","key":"e_1_2_7_98_1","first-page":"81","article-title":"Protective effect of black grapes seed hydroalcholic extract against fluoxetine\u2010induced embryo toxicity in male mice","volume":"7","author":"Hajizadeh Z.","year":"2013","journal-title":"International Journal of Fertility & Sterility"},{"issue":"12","key":"e_1_2_7_99_1","first-page":"352","article-title":"Grape seed extract alleviate reproductive toxicity caused by aluminium chloride in male rats","volume":"6","author":"Hala A.","year":"2010","journal-title":"Journal of American Science"},{"issue":"3","key":"e_1_2_7_100_1","first-page":"293","article-title":"Resveratrol protects against acute chemotherapy toxicity induced by doxorubucin in rat erythrocyte and plasma","volume":"63","author":"Hamlaoui S.","year":"2012","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"25","key":"e_1_2_7_101_1","first-page":"6076","article-title":"Grape seed extract mitigates garlic\u2010induced oxidative stress in rat spleen and plasma","volume":"5","author":"Hamlaoui\u2010Gasmi S.","year":"2011","journal-title":"Journal of Medicinal Plant Research"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705688"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069452"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.07.010"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-013-9589-8"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.194142"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-013-0461-1"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.04.004"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.05.004"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.4.237"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2009.0635"},{"key":"e_1_2_7_112_1","article-title":"Effect of Saffron extract on Acrylamide\u2010induced toxicity: In vitro and in vivo assessment","author":"Hosseinzadeh H.","year":"2014","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1769"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20734"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029102"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.04.005"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.876"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.03.027"},{"key":"e_1_2_7_119_1","volume-title":"Environmental health criteria 202: Selected non\u2010heterocyclic polycyclic aromatic hydrocarbons, international programme on chemical safety (IPCS)","author":"Jacob J.","year":"1998"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00062-5"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2012.03.005"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00280-8"},{"issue":"02","key":"e_1_2_7_123_1","first-page":"87","article-title":"Protective effects of hydroalcoholic extract of red grape seed (VITIS VENIFERA) in nephrotoxicity induced by amikacin in mice","volume":"2007","author":"Kalantari H.","year":"2007","journal-title":"Jundishapur Journal of Natural Pharmaceutical Products"},{"issue":"11","key":"e_1_2_7_124_1","first-page":"539","article-title":"Protective antioxidant effects of grape seed extract in a cisplatin\u2010induced hepatotoxicity model in rabbits","volume":"163","author":"Kandemir F.","year":"2012","journal-title":"Revue de M\u00e9decine V\u00e9t\u00e9rinaire"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015911795017353"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.11.044"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.05.004"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2010.24.2.108"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.159"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0208"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2012.672144"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.04.001"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200609000-00014"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft146"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm128"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.06.010"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.08.040"},{"issue":"4","key":"e_1_2_7_138_1","first-page":"272","article-title":"Grape seed proanthocyanidin extract alleviates arsenic\u2010induced oxidative reproductive toxicity in male mice","volume":"28","author":"Li S. G.","year":"2015","journal-title":"Biomedical and Environmental Sciences"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2008.00358.x"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.3136\/fstr.22.403"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg014"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjp.v10i2.22588"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15011625"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00001"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13233"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn120"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-014-0147-5"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.03.012"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TX00260E"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14056"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8100656"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060808"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.07.004"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2015.9.1.37"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327112440113"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1782"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/398285"},{"key":"e_1_2_7_158_1","unstructured":"Maughan T. Pace M. &Black B.(2017).Grape vine management All Current Publications. p. 1655."},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59755"},{"issue":"9","key":"e_1_2_7_160_1","first-page":"902","article-title":"Crocin reduced acrylamide\u2010induced neurotoxicity in Wistar rat through inhibition of oxidative stress","volume":"18","author":"Mehri S.","year":"2015","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9752-8"},{"issue":"1","key":"e_1_2_7_162_1","first-page":"159","article-title":"Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: Studies in an animal model","volume":"18","author":"Melamed E.","year":"1982","journal-title":"Israel Journal of Medical Sciences"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.11.010"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.2.6"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-163"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712001356"},{"issue":"5","key":"e_1_2_7_167_1","first-page":"538","article-title":"Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities","volume":"20","author":"Mohammadzadeh N.","year":"2017","journal-title":"Iranian Journal of Basic Medical Sciences"},{"issue":"6","key":"e_1_2_7_168_1","first-page":"1971","article-title":"Efficacy of grape seed and skin extract against doxorubicin\u2010induced oxidative stress in rat liver","volume":"28","author":"Mokni M.","year":"2015","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308602762197434"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014575"},{"key":"e_1_2_7_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2761"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5644"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.2002.4352"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.10.005"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.08.011"},{"key":"e_1_2_7_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/np5003143"},{"issue":"4","key":"e_1_2_7_177_1","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/S0021-9258(18)45903-0","article-title":"DNA strand scission and free radical production in menadione\u2010treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase","volume":"267","author":"Nutter L. M.","year":"1992","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"e_1_2_7_178_1","first-page":"467","article-title":"The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds","volume":"55","author":"Olas B.","year":"2004","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"2","key":"e_1_2_7_179_1","first-page":"145","article-title":"Molecular mechanisms of protective effect of resveratrol against cisplatinium induced ototoxicity","volume":"9","author":"Olgun Y.","year":"2013","journal-title":"The Journal of International Advanced Otology"},{"key":"e_1_2_7_180_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-014-0152-2"},{"key":"e_1_2_7_181_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2012.656563"},{"key":"e_1_2_7_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.04.022"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.01.003"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6705621"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12260588"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800898p"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-003-0458-1"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.037"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.03.008"},{"key":"e_1_2_7_190_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064372"},{"key":"e_1_2_7_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.12.021"},{"issue":"3","key":"e_1_2_7_192_1","first-page":"258","article-title":"Grape (Vitis vinifera) seed extract inhibits the cytotoxicity and oxidative stress in liver of rats treated with carbon tetrachloride","volume":"7","author":"Ragab G. M. A.","year":"2013","journal-title":"Global Journal of Pharmacology"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25242"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10767"},{"issue":"4","key":"e_1_2_7_195_1","first-page":"891","article-title":"Resveratrol mediated protection of dacarbazine\u2010induced mutagenicity in mice","volume":"8","author":"Ramadan A. M. A.","year":"2011","journal-title":"Life Science Journal"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.11.035"},{"key":"e_1_2_7_197_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40199-015-0112-y"},{"key":"e_1_2_7_198_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.055"},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.916"},{"issue":"3","key":"e_1_2_7_200_1","first-page":"301","article-title":"Exploring cyclosporine A\u2010side effects and the protective role\u2010played by antioxidants: The morphological and immunohistochemical studies","volume":"21","author":"Rezzani R.","year":"2006","journal-title":"Histology and Histopathology"},{"key":"e_1_2_7_201_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/703676"},{"key":"e_1_2_7_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.03.043"},{"issue":"4","key":"e_1_2_7_203_1","first-page":"285","article-title":"Protective effect of grape seed extract on gentamicin\u2010induced acute kidney injury","volume":"4","author":"Safa J.","year":"2010","journal-title":"Iranian Journal of Kidney Diseases"},{"key":"e_1_2_7_204_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.125167"},{"key":"e_1_2_7_205_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO00191B"},{"issue":"4","key":"e_1_2_7_206_1","first-page":"484","article-title":"Manganese exposure, essentiality & toxicity","volume":"128","author":"Santamaria A. B.","year":"2008","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030500309319"},{"key":"e_1_2_7_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-0994-0"},{"key":"e_1_2_7_209_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802555577"},{"key":"e_1_2_7_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2007.08.023"},{"key":"e_1_2_7_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.07.003"},{"key":"e_1_2_7_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.08.011"},{"key":"e_1_2_7_213_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0088"},{"key":"e_1_2_7_214_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.138867"},{"issue":"5","key":"e_1_2_7_215_1","first-page":"933","article-title":"Hepatoprotective activity of Vitis vinifera root extract against carbon tetrachloride\u2010induced liver damage in rats","volume":"69","author":"Sharma S. K.","year":"2012","journal-title":"Acta Poloniae Pharmaceutica"},{"key":"e_1_2_7_216_1","doi-asserted-by":"publisher","DOI":"10.1080\/01483919008049014"},{"key":"e_1_2_7_217_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003"},{"key":"e_1_2_7_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22099"},{"key":"e_1_2_7_219_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.v20.i2.70"},{"key":"e_1_2_7_220_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.79"},{"key":"e_1_2_7_221_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074453"},{"key":"e_1_2_7_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000206"},{"key":"e_1_2_7_223_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233714566874"},{"key":"e_1_2_7_224_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12260"},{"key":"e_1_2_7_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.02.005"},{"key":"e_1_2_7_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(91)90031-R"},{"key":"e_1_2_7_227_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2011.556156"},{"key":"e_1_2_7_228_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1459"},{"key":"e_1_2_7_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1221"},{"key":"e_1_2_7_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(83)90177-3"},{"issue":"5","key":"e_1_2_7_231_1","first-page":"557","article-title":"A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome","volume":"20","author":"Tabeshpour J.","year":"2017","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_7_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5805"},{"issue":"7","key":"e_1_2_7_233_1","first-page":"769","article-title":"Resveratrol can prevent CCl\u2084\u2010induced liver injury by inhibiting Notch signaling pathway","volume":"31","author":"Tanriverdi G.","year":"2016","journal-title":"Histology and Histopathology"},{"key":"e_1_2_7_234_1","first-page":"2","article-title":"Black seed (Nigella Sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities","volume":"16","author":"Tavakkoli A.","year":"2017","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_7_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2006.07.008"},{"key":"e_1_2_7_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90319-R"},{"key":"e_1_2_7_237_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050100406"},{"key":"e_1_2_7_238_1","doi-asserted-by":"publisher","DOI":"10.2165\/11316640-000000000-00000"},{"key":"e_1_2_7_239_1","doi-asserted-by":"publisher","DOI":"10.18433\/J30K5Q"},{"key":"e_1_2_7_240_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-89132013000300008"},{"key":"e_1_2_7_241_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711414614"},{"key":"e_1_2_7_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(00)00097-6"},{"key":"e_1_2_7_243_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01565.x"},{"key":"e_1_2_7_244_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.16216"},{"key":"e_1_2_7_245_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01615.x"},{"key":"e_1_2_7_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.03.004"},{"key":"e_1_2_7_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.08.019"},{"key":"e_1_2_7_248_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00335.x"},{"key":"e_1_2_7_249_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbbs.2012.22021"},{"key":"e_1_2_7_250_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9093354"},{"key":"e_1_2_7_251_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2009.0679"},{"key":"e_1_2_7_252_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-6883-z"},{"key":"e_1_2_7_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.05.001"},{"key":"e_1_2_7_254_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2862-2_1"},{"key":"e_1_2_7_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70365-3"},{"key":"e_1_2_7_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310129"},{"key":"e_1_2_7_257_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4514.2009.00276.x"},{"key":"e_1_2_7_258_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11020622"},{"key":"e_1_2_7_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.03.009"},{"key":"e_1_2_7_260_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.0162"},{"key":"e_1_2_7_261_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/137919"},{"key":"e_1_2_7_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2011.01.012"},{"key":"e_1_2_7_263_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200712250"},{"key":"e_1_2_7_264_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9272-x"},{"issue":"9","key":"e_1_2_7_265_1","first-page":"514","article-title":"Resveratrol protects against triptolide\u2010induced cardiotoxicity through SIRT3 signaling pathway in vivo and in vitro","volume":"71","author":"Yang Y.","year":"2016","journal-title":"Die Pharmazie"},{"issue":"4","key":"e_1_2_7_266_1","first-page":"473","article-title":"Comparable molecular alterations in 4\u2010nitroquinoline 1\u2010oxide\u2010induced oral and esophageal cancer in mice and in human esophageal cancer, associated with poor prognosis of patients","volume":"27","author":"Yang Z.","year":"2013","journal-title":"In Vivo"},{"issue":"5","key":"e_1_2_7_267_1","first-page":"973","article-title":"The comparison of resveratrol and N\u2010acetylcysteine on the oxidative kidney damage caused by high dose paracetamol","volume":"34","author":"Yapanoglu T.","year":"2015","journal-title":"Latin American Journal of Pharmacy"},{"key":"e_1_2_7_268_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3283457743"},{"key":"e_1_2_7_269_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.47.28228"},{"key":"e_1_2_7_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.02.006"},{"key":"e_1_2_7_271_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1026-4"},{"key":"e_1_2_7_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.12.052"},{"key":"e_1_2_7_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.12.021"},{"key":"e_1_2_7_274_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2015.1026808"},{"key":"e_1_2_7_275_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.064535"},{"key":"e_1_2_7_276_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1381"},{"key":"e_1_2_7_277_1","doi-asserted-by":"publisher","DOI":"10.1080\/20024091064165"},{"key":"e_1_2_7_278_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2014.8.2.220"},{"key":"e_1_2_7_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.09.023"},{"key":"e_1_2_7_280_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357056523"},{"key":"e_1_2_7_281_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/617202"},{"key":"e_1_2_7_282_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12815"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:10:02Z","timestamp":1694848202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,8]]},"references-count":281,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/ptr.6168"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6168","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,8]]},"assertion":[{"value":"2018-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}