{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:09:27Z","timestamp":1768788567481,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RSA5680012"],"award-info":[{"award-number":["RSA5680012"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p><jats:italic>Curcuma zedoaroides<\/jats:italic>, a Zingiberaceae species, has been used for snake bite antidote and wound care in Thailand. Seven compounds were isolated from the bioactive chloroform extract consisted of one new guaiane sesquiterpene lactone, 5\u2010epiphaeocaulisin A (<jats:bold>4<\/jats:bold>) and one new diarylheptanoid, 1,2,3,5\u2010tetrahydroxy\u20101\u2010(4\u2010hydroxy\u20103\u2010methoxyphenyl)\u20107\u2010(4\u2010hydroxyphenyl) heptane (<jats:bold>7<\/jats:bold>), together with five known guaiane\u2010type sesquiterpene lactones including gweicurculactone (<jats:bold>1<\/jats:bold>), zedoalactone B (<jats:bold>2<\/jats:bold>), phaeocaulisin C (<jats:bold>3<\/jats:bold>), zedoalactone H (<jats:bold>5<\/jats:bold>), and zedoalactone E (<jats:bold>6<\/jats:bold>). The antiinflammation was investigated on NO and TNF\u2010\u03b1 production using RAW264.7 cells. In addition, the expressions of genes involved in inflammation including iNOS, COX\u20102, and TNF\u2010\u03b1 were assessed. The results found that Compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>7<\/jats:bold> presented their antiinflammation against NO production. The most potential effects were demonstrated on Compounds <jats:bold>1<\/jats:bold> and <jats:bold>7<\/jats:bold> with IC<jats:sub>50<\/jats:sub> of 27.3 and 32.6\u00a0\u03bcM, respectively. Although, Compounds <jats:bold>1<\/jats:bold> and <jats:bold>7<\/jats:bold> did not inhibit TNF\u2010\u03b1 production, their suppression on iNOS and COX\u20102 mRNA expression were revealed. These results support the ability of chloroform fraction, Compounds <jats:bold>1<\/jats:bold> and <jats:bold>7<\/jats:bold> on antiinflammation, whereas others exhibited moderate and mild effect.<\/jats:p>","DOI":"10.1002\/ptr.6173","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T07:53:32Z","timestamp":1534319612000},"page":"2312-2320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antiinflammation constituents from <scp><i>Curcuma zedoaroides<\/i><\/scp>"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-2883","authenticated-orcid":false,"given":"Pattreeya","family":"Tungcharoen","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchai","family":"Wattanapiromsakul","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"},{"name":"Excellent Research laboratory, Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pimpimon","family":"Tansakul","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"},{"name":"Excellent Research laboratory, Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seikou","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Division of Medicinal Chemical Sciences Kyoto Pharmaceutical University  Misasagi, Yamashina\u2010ku Kyoto 607\u20108412 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Division of Medicinal Chemical Sciences Kyoto Pharmaceutical University  Misasagi, Yamashina\u2010ku Kyoto 607\u20108412 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-6232","authenticated-orcid":false,"given":"Supinya","family":"Tewtrakul","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"},{"name":"Excellent Research laboratory, Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai Songkhla 90112 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)93618-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612780"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"80","article-title":"Two new species of Curcuma (Zingiberaceae) used as cobra\u2010bite antidotes","volume":"46","author":"Chaveerach A.","year":"2008","journal-title":"Journal of Systematics and Evolution"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1641"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80153-1"},{"key":"e_1_2_7_7_1","first-page":"357","article-title":"Studies on the chemical constituents of Curcuma kwangsiensis","volume":"24","author":"Jiang D. 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