{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:11:37Z","timestamp":1775337097777,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Curcumin is a polyphenol present in the rhizomes of the species <jats:styled-content style=\"fixed-case\"><jats:italic>Curcuma longa<\/jats:italic><\/jats:styled-content> L. (\u201cturmeric,\u201d Zingiberaceae), which has been used for centuries as an anti\u2010inflammatory. We aimed to evaluate the anti\u2010inflammatory effects of <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0longa<\/jats:italic><\/jats:styled-content> in renal injury induced by doxorubicin (DOX, 3.5\u00a0mg.kg<jats:sup>\u22121<\/jats:sup> IV). We studied four groups of Wistar rats: two groups with DOX\u2010induced kidney injury, one fed with standard food and another with standard food mixed with <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0longa<\/jats:italic><\/jats:styled-content> (5\u00a0mg.g<jats:sup>\u22121<\/jats:sup>). Two other control groups without kidney injury were fed with the same foods. We measured albuminuria, body weight, and food intake every 2\u00a0weeks. After 8\u00a0weeks, treatment with <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0longa<\/jats:italic><\/jats:styled-content> did not change albuminuria, but it significantly attenuated the excretion of urinary inflammatory markers monocyte chemoattractant protein\u20101 (MCP\u20101) and transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) and significantly attenuated immunostaining for desmin, vimentin, and ED\u20101<jats:sup>+<\/jats:sup> cells in renal tissues of rats with DOX\u2010induced kidney injury. In addition, treatment with <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0longa<\/jats:italic><\/jats:styled-content> resulted in significantly lower glomerular and tubule interstitial injury scores, compared with that in the DOX\u2010STD group. In conclusion, administration of powdered rhizomes of <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0longa<\/jats:italic><\/jats:styled-content> for 8\u00a0weeks to rats with DOX\u2010induced kidney injury did not reduce albuminuria but led to a significant decrease in urinary inflammatory markers MCP\u20101 and TGF\u2010\u03b2 and decreased histopathological alterations and immunostaining for desmin, vimentin, and ED\u20101<jats:sup>+<\/jats:sup> cells kidneys tissues.<\/jats:p>","DOI":"10.1002\/ptr.6176","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T08:09:54Z","timestamp":1534320594000},"page":"2408-2416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Oral administration of powdered dried rhizomes of <scp><i>Curcuma longa<\/i><\/scp> L. (turmeric, Zingiberaceae) is effective in the treatment of doxorubicin\u2010induced kidney injury in rats"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-6204","authenticated-orcid":false,"given":"Enzo R.","family":"Russo","sequence":"first","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inalda","family":"Facincani","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia C.","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terezila M.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo J.","family":"Crevelin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto University of S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-4718","authenticated-orcid":false,"given":"Ana Maria S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Ribeir\u00e3o Preto (UNAERP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-0325","authenticated-orcid":false,"given":"Fabio","family":"Carmona","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368940"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5524"},{"issue":"2","key":"e_1_2_6_4_1","first-page":"111","article-title":"Herbal medicines for immunosuppression","volume":"11","author":"Amirghofran Z.","year":"2012","journal-title":"Iranian Journal of Allergy, Asthma, and Immunology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.44591"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5905"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.212"},{"issue":"1","key":"e_1_2_6_8_1","first-page":"16","article-title":"Adriamycin\u2010induced nephrotic syndrome in rats: Sequence of pathologic events","volume":"46","author":"Bertani T.","year":"1982","journal-title":"Laboratory Investigation"},{"key":"e_1_2_6_9_1","unstructured":"Carvalho G. 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