{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:01:05Z","timestamp":1767085265726,"version":"3.37.3"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["PJ01256601"],"award-info":[{"award-number":["PJ01256601"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>This study investigated the effects of oligonol, a low\u2010molecular\u2010polyphenol derived from lychee peel, against diabetes\u2010induced pancreatic damage via oxidative stress\u2010induced inflammation. Oligonol was orally administered at 10 or 20\u00a0mg\/kg body weight\/day for 10\u00a0days to streptozotocin\u2010induced diabetic rats, and the rats were compared with nondiabetic and diabetic control rats. The diabetic rats showed loss of body weight and increased pancreatic weight, and the oral administration of oligonol attenuated these parameters. Moreover, the administration of oligonol caused a significant decrease in the serum glucose level and a significant increase in the serum and pancreatic insulin and C\u2010peptide levels in the diabetic rats. Oligonol also significantly reduced the enhanced levels of reactive oxygen species and 2\u2010thiobarbituric acid reactive substance, which are oxidative stress biomarkers, in the serum and pancreas. Oligonol treatment reduced the overexpression of phospho\u2010p38, phospho\u2010ERK1\/2, phospho\u2010inhibitor of nuclear factor\u2010kappa B (NF\u2010\u03baB), NF\u2010\u03baBp65, and NF\u2010\u03baBp65\u2010induced inflammatory protein such as cyclooxygenase\u20102, inducible nitric oxide synthase, tumor necrosis factor\u2010\u03b1, and interleukin\u20106. Furthermore, oligonol treatment led to significantly attenuated histological damage in the pancreas. On the basis of these results, we conclude that a plausible mechanism of oligonol's antidiabetic action may be its antioxidative stress\u2010related anti\u2010inflammatory action.<\/jats:p>","DOI":"10.1002\/ptr.6194","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T06:26:15Z","timestamp":1538547975000},"page":"2541-2550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oligonol, a low\u2010molecular\u2010weight polyphenol derived from lychee peel, attenuates diabetes\u2010induced pancreatic damage by inhibiting inflammatory responses via oxidative stress\u2010dependent mitogen\u2010activated protein kinase\/nuclear factor\u2010kappa B signaling"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-7159","authenticated-orcid":false,"given":"Chan Hum","family":"Park","sequence":"first","affiliation":[{"name":"Department of Medicinal Crop Research National Institute of Horticultural and Herbal Science, Rural Development Administration  Eumseong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong Hun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicinal Crop Research National Institute of Horticultural and Herbal Science, Rural Development Administration  Eumseong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5214-8061","authenticated-orcid":false,"given":"Seung Gil","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering National Institute of Agricultural Sciences, Rural Development Administration  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Su","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering National Institute of Agricultural Sciences, Rural Development Administration  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering National Institute of Agricultural Sciences, Rural Development Administration  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering National Institute of Agricultural Sciences, Rural Development Administration  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Wook","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering National Institute of Agricultural Sciences, Rural Development Administration  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Yokozawa","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering for Research University of Toyama  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2015.9.2.123"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"637","article-title":"Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity","volume":"13","author":"Ali S. 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