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We searched for available small\u2010molecule inhibitors of the NLRP3 inflammasome that could be topically administered for the treatment of acne. We found that licochalcone A, a chalconoid isolated from the root of\n                    <jats:italic>Glycyrrhiza inflate<\/jats:italic>\n                    , was an effective inhibitor for\n                    <jats:italic>P<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>acnes<\/jats:italic>\n                    \u2010induced NLRP3 inflammasome activation. Licochalcone A blocked\n                    <jats:italic>P<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>acnes\u2010<\/jats:italic>\n                    induced production of caspase\u20101(p10) and IL\u20101\u03b2 in primary mouse macrophages and human SZ95 sebocytes, indicating the suppression of NLRP3 inflammasome. Licochalcone A suppressed\n                    <jats:italic>P<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>acnes\u2010<\/jats:italic>\n                    induced ASC speck formation and mitochondrial reactive oxygen species. Topical application of licochalcone A to mouse ear skin attenuated\n                    <jats:italic>P<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>acnes<\/jats:italic>\n                    \u2010induced skin inflammation as shown by histological assessment, ear thickness measurement, and inflammatory gene expression. Licochalcone A reduced caspase\u20101 activity and IL\u20101\u03b2 production in mouse ear injected with\n                    <jats:italic>P<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>acnes<\/jats:italic>\n                    . This study demonstrated that licochalcone A is effective in the control of\n                    <jats:italic>P<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>acnes\u2010<\/jats:italic>\n                    induced skin inflammation as an efficient inhibitor for NLRP3 inflammasome. Our study provides a new paradigm for the development of anti\u2010acne therapy via targeting NLRP3 inflammasome.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6195","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T09:36:11Z","timestamp":1538732171000},"page":"2551-2559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome"],"prefix":"10.1002","volume":"32","author":[{"given":"Gabsik","family":"Yang","sequence":"first","affiliation":[{"name":"BK21plus team, College of Pharmacy The Catholic University of Korea  Bucheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"BK21plus team, College of Pharmacy The Catholic University of Korea  Bucheon 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