{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:15:51Z","timestamp":1790320551072,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473454"],"award-info":[{"award-number":["81473454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774164"],"award-info":[{"award-number":["81774164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473557"],"award-info":[{"award-number":["81473557"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Berberine, a natural isoquinoline alkaloid isolated from the <jats:italic>berberis<\/jats:italic> species, has a wide array of biological properties such as anti\u2010inflammatory, antibacterial, antifungal, and antihelminthic effects. We evaluated the antiviral effect of berberine against influenza A\/FM1\/1\/47 (H1N1) in vivo and in vitro. The results showed that berberine strongly suppressed viral replication in A549 cells and in mouse lungs. Meanwhile, berberine relieved pulmonary inflammation and reduced necrosis, inflammatory cell infiltration, and pulmonary edema induced by viral infection in mice when compared with vehicle\u2010treated mice. Berberine suppressed the viral infection\u2010induced up\u2010regulation of TLR7 signaling pathway, such as TLR7, MyD88, and NF\u2010\u03baB (p65), at both the mRNA and protein levels. Furthermore, berberine significantly inhibited the viral infection\u2010induced increase in Th1\/Th2 and Th17\/Treg ratios as well as the production of inflammatory cytokines. Our data provide new insight into the potential of berberine as a therapeutic agent for viral infection via its antiviral activity.<\/jats:p>","DOI":"10.1002\/ptr.6196","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T07:44:54Z","timestamp":1539243894000},"page":"2560-2567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Anti\u2010influenza activity of berberine improves prognosis by reducing viral replication in mice"],"prefix":"10.1002","volume":"32","author":[{"given":"Yu\u2010Qi","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Basic Medicine College Jinan University  GuangZhou China"},{"name":"Guangdong Key Laboratory of Molecular Immunology and Antibody Engineering Jinan University  GuangZhou China"},{"name":"Guangdong Province Engineering Research Center for Antibody Drug and Immunoassay Jinan University  GuangZhou 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