{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:39:12Z","timestamp":1780367952347,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["253037"],"award-info":[{"award-number":["253037"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["380833"],"award-info":[{"award-number":["380833"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Stevia has been shown to prevent oxidative stress and inflammation in carbon tetrachloride\u2010induced cirrhosis models. This study aimed to investigate the ability of an aqueous extract of stevia (AES) to prevent thioacetamide (TAA)\u2010induced cirrhosis in rats and to explore its mechanism of action. Liver cirrhosis was established by administering TAA (200\u00a0mg\/kg by i.p. injections three times a week for 10\u00a0weeks); AES was administered (100\u00a0mg\/kg by gavage daily) during the TAA treatment. Liver damage and fibrosis were evaluated, and the profibrotic pathways were analyzed by western blotting and immunohistochemistry. TAA increased nuclear factor kappa B (NF\u2010\u03baB) and pro\u2010inflammatory cytokine production, as well as the malondialdehyde and 4\u2010hydroxynonenal levels, whereas the glutathione\/glutathione disulfide and nuclear factor\u2010E2\u2010related factor 2 (Nrf2) levels were decreased. Moreover, TAA increased collagen production, hepatic stellate cell (HSC) activation, and expression of profibrogenic mediators. TAA\u2010treated rats that had been exposed to Mn2+ exhibited altered striatal dopamine turnover, indicating hepatic encephalopathy. AES partially or completely prevented all of these effects. AES showed antioxidant, anti\u2010inflammatory, and antifibrotic properties, probably because of its capacity to induce Nrf2 expression, reduce NF\u2010\u03baB expression, and block several profibrogenic signaling pathways, subsequently inhibiting HSC activation and preventing fibrosis and dopamine turnover.<\/jats:p>","DOI":"10.1002\/ptr.6197","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T06:40:31Z","timestamp":1537857631000},"page":"2568-2576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Stevia rebaudiana<\/i>tea prevents experimental cirrhosis via regulation of NF\u2010\u03baB, Nrf2, transforming growth factor beta, Smad7, and hepatic stellate cell activation"],"prefix":"10.1002","volume":"32","author":[{"given":"Erika","family":"Ramos\u2010Tovar","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Hepatology, Department of Pharmacology 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