{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:27:07Z","timestamp":1788294427974,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences","award":["9773"],"award-info":[{"award-number":["9773"]}]},{"name":"Behnam Daheshpour Charity Organization"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Clinical potential of curcumin in radiotherapy (RT) setting is outstanding and of high interest. The main purpose of this randomized controlled trial (RCT) was to assess the beneficial role of nanocurcumin to prevent and\/or mitigate radiation\u2010induced proctitis in prostate cancer patients undergoing RT. In this parallel\u2010group study, 64 eligible patients with prostate cancer were randomized to receive either oral nanocurcumin (120\u00a0mg\/day) or placebo 3\u00a0days before and during the RT course. Acute toxicities including proctitis and cystitis were assessed weekly during the treatment and once thereafter using CTCAE v.4.03 grading criteria. Baseline\u2010adjusted hematologic nadirs were also analyzed and compared between the two groups. The patients undergoing definitive RT were followed to evaluate the tumor response. Nanocurcumin was well tolerated. Radiation\u2010induced proctitis was noted in 18\/31 (58.1%) of the placebo\u2010treated patients versus 15\/33 (45.5%) of nanocurcumin\u2010treated patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.313). No significant difference was also found between the two groups with regard to radiation\u2010induced cystitis, duration of radiation toxicities, hematologic nadirs, and tumor response. In conclusion, this RCT was underpowered to indicate the efficacy of nanocurcumin in this clinical setting but could provide a considerable new translational insight to bridge the gap between the laboratory and clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6230","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T05:19:54Z","timestamp":1542172794000},"page":"370-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Randomized, double\u2010blind, placebo\u2010controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Afshin","family":"Saadipoor","sequence":"first","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Razzaghdoust","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center, Student Research Committee Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Simforoosh","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Modarres Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Bakhshandeh","sequence":"additional","affiliation":[{"name":"Department of Radiology Technology, Allied Medical Faculty Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Shohada\u2010e\u2010Tajrish Medical Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-3510","authenticated-orcid":false,"given":"Bahram","family":"Mofid","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0606-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5998"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.32"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24967"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40854-5_4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.07.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2003)159[0283:SARIAO]2.0.CO;2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26301"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.05.018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02721-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00002350"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-018-0473-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19164"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2010.509835"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1547337"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-017-1742-8"},{"issue":"10","key":"e_1_2_7_19_1","article-title":"Curcumin: A review of its' effects on human health","volume":"6","author":"Hewlings S. 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