{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:59:19Z","timestamp":1792425559760,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Antidepressant drugs are associated with many challenges due to their adverse impacts. Seeking alternatives through medicinal plants could have a great merit in overcoming these deleterious effects. This study was designed to investigate the potential mechanism of curcumin (CUR) in modifying the depression\u2010like behaviour in ovariectomised (OVX) rats, inference with fluoxetine (FLX) and oestradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ). The treatments of OVX rats started after 1\u00a0month post ovariectomy and proceeded for 1\u00a0month. The experimental animals were divided into five groups: sham\u2010operated, OVX\u2010, OVX\u2010FLX (20\u00a0mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , i.p., daily), OVX\u2010E\n                    <jats:sub>2<\/jats:sub>\n                    (100\u00a0\u03bcg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , i.m., every other day), and OVX\u2010CUR\u2010 (100\u00a0mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p.o., daily) treated groups. The results showed that CUR modulated the depression\u2010like behaviour using forced swimming test. It improved the serotonin content in many brain regions by upregulating tryptophan hydroxylase\u20102 and 5\u2010hydroxytryptamine\n                    <jats:sub>1A,2A<\/jats:sub>\n                    receptor messenger RNA (mRNA) and downregulating monoamine oxidase A mRNA in the limbic system. Furthermore, it upregulated aromatase, brain\u2010derived neurotropic factor mRNA, and extracellular\u2010regulated kinase 1\/2 protein in the limbic system, relative to FLX and E\n                    <jats:sub>2,<\/jats:sub>\n                    compared with OVX group. In conclusion, CUR appears to be safe and efficient agent as serotonin modulator similar to FLX and neurotrophic agent like E\n                    <jats:sub>2<\/jats:sub>\n                    , in improving the depression\u2010like behaviour in OVX rats.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6232","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T10:19:59Z","timestamp":1545387599000},"page":"387-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Involvement of the serotonergic system and neuroplasticity in the antidepressant effect of curcumin in ovariectomized rats: Comparison with oestradiol and fluoxetine"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-1556","authenticated-orcid":false,"given":"Marwa M.","family":"Abd\u2010Rabo","sequence":"first","affiliation":[{"name":"Department of hormone National Organization 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