{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:29:09Z","timestamp":1762018149902,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>The hepatoprotective activity of praecoxin A, an ellagitannin from <jats:styled-content style=\"fixed-case\"><jats:italic>Melaleuca ericifolia<\/jats:italic><\/jats:styled-content>, was determined against CCl<jats:sub>4<\/jats:sub>\u2010induced toxicity in mice. Praecoxin A was administered (25, 50, and 100\u00a0mg\/kg) for 5\u00a0days followed by CCl<jats:sub>4<\/jats:sub>. Praecoxin A markedly ameliorated the CCl<jats:sub>4<\/jats:sub>\u2010induced increase in AST (by 19, 52, and 56%), ALP (22, 45, and 48%), ALT (11, 47, and 54%), total bilirubin (14, 27, and 28%), and MDA (26, 44, and 51%) at the tested doses, respectively, as compared with CCl<jats:sub>4<\/jats:sub> group. It was evident that praecoxin A significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) increased the antioxidant parameters GSH (45, 99, and 137%) and SOD (61, 129, and 159%). Histological findings revealed a marked amelioration of hepatocyte degeneration, necrosis, inflammatory cell infiltration, and hemorrhage in the groups treated with praecoxin A. COX\u20102 and caspase\u20103 hepatic expressions were significantly downregulated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in praecoxin A\u2010treated groups (up to 57, 83, and 93% for COX\u20102 and by 30, 82, and 99% for caspase\u20103). These findings suggest that praecoxin A exerts a beneficial effect against oxidative stress by reducing lipid peroxidation, enhancing the antioxidant defense status, and protecting against the histopathological changes induced by CCl<jats:sub>4<\/jats:sub>. This study highlights a promising natural hepatoprotective candidate derived from <jats:styled-content style=\"fixed-case\"><jats:italic>M.\u00a0ericifolia<\/jats:italic><\/jats:styled-content> that might be an alternative to silymarin.<\/jats:p>","DOI":"10.1002\/ptr.6242","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T08:40:41Z","timestamp":1543826441000},"page":"461-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hepatoprotective activity of praecoxin A isolated from <scp><i>Melaleuca ericifolia<\/i><\/scp> against carbon tetrachloride\u2010induced hepatotoxicity in mice. 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