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Rats were treated with BPA (0 and 35\u00a0mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    , gavage) plus resveratrol (25, 50, and 100\u00a0mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    , i.p.) or GSE (3, 6, 12\u00a0mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    , i.p.) or vitamin E (200\u00a0IU\/kg\/every other day, i.p.). After 2\u00a0months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme\u2010linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real\u2010time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (\n                    <jats:italic>LDLR<\/jats:italic>\n                    ,\n                    <jats:italic>CYP7A1<\/jats:italic>\n                    ,\n                    <jats:italic>ABCG5<\/jats:italic>\n                    and\n                    <jats:italic>8<\/jats:italic>\n                    ) and insulin signaling (p\u2010Akt\/Akt and p\u2010PI3K\/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low\u2010density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both\n                    <jats:italic>ABCG5<\/jats:italic>\n                    and\n                    <jats:italic>ABCG8<\/jats:italic>\n                    . It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p\u2010Akt\/Akt and p\u2010PI3K\/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels.\n                  <\/jats:p>\n                  <jats:p>\n                    Herein, the predisposing effects of BPA\u2010induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling,\n                    <jats:italic>ABCG8<\/jats:italic>\n                    expression, and their antioxidant properties.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6276","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T12:56:44Z","timestamp":1547729804000},"page":"832-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>Vitis vinifera<\/i>\n                    (grape) seed extract and resveratrol alleviate bisphenol\u2010A\u2010induced metabolic syndrome: Biochemical and molecular evidences"],"prefix":"10.1002","volume":"33","author":[{"given":"Maryam","family":"Rameshrad","sequence":"first","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi Marjan","family":"Razavi","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Imenshahidi","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad 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