{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:30:30Z","timestamp":1768825830831,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brasi","award":["finance code 001"],"award-info":[{"award-number":["finance code 001"]}]},{"name":"Postgraduate Research Group, Hospital de Cl\u00ednicas de Porto Alegre","award":["GPPG\/FIPE:14-0613"],"award-info":[{"award-number":["GPPG\/FIPE:14-0613"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>We explored the effects of a mucoadhesive formulation containing curcuminoid (MFC) from <jats:styled-content style=\"fixed-case\"><jats:italic>Curcuma longa<\/jats:italic><\/jats:styled-content> L. extract on oral mucositis (OM) induced by 5\u2010fluorouracil (5\u2010FU) in hamsters. Seventy\u2010two golden Syrian hamsters were randomly allocated into four groups: control, placebo, chamomilla, and MFC. Animals received an intraperitoneal injection of 5\u2010FU at Days 0 and 2. On Days 3 and 4, the buccal mucosa was scratched. Therapy was initiated on Day 5. Animals received two applications of the substances per day according to the experimental group. Six animals were euthanized on Days 8, 10, and 14. Clinical analysis were performed using photography and histopathological sections of 3\u00a0\u03bcm were stained by hematoxylin\u2013eosin for semiquantitative analysis of re\u2010epithelization and inflammation. Immunohistochemistry was used for angiogenesis (CD31) and transforming growth factor beta 1 (TGF\u2010\u03b21) analysis. On Day 5, all groups exhibited OM. Clinical and histopathological findings revealed that on Day 8, both MFC and chamomilla groups exhibited better wound healing. In addition, the MFC group demonstrated lower angiogenesis and TGF\u2010\u03b21 levels on Day 8 compared with placebo and control groups. Collectively, these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re\u2010epithelization and anti\u2010inflammatory action as modulation of angiogenesis and TGF\u2010\u03b21 expression.<\/jats:p>","DOI":"10.1002\/ptr.6279","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T13:17:15Z","timestamp":1548335835000},"page":"881-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mucoadhesive formulation containing <scp><i>Curcuma longa<\/i><\/scp> L. reduces oral mucositis induced by 5\u2010fluorouracil in hamsters"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-2272","authenticated-orcid":false,"given":"Tuany Rafaeli","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-9424","authenticated-orcid":false,"given":"Marina","family":"Curra","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-2135","authenticated-orcid":false,"given":"Vivian Petersen","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7834-3319","authenticated-orcid":false,"given":"Marco Antonio Trevizani","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Department of Oral Medicine, Porto Alegre Clinics Hospital (HCPA\/UFRGS) Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-7534","authenticated-orcid":false,"given":"Aline Carlos","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-5593","authenticated-orcid":false,"given":"Aline Carvalho","family":"Batista","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Pathology, School of Dentistry Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-1325","authenticated-orcid":false,"given":"Marize Campos","family":"Valadares","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Cellular Toxicology, Pharmacy Faculty Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3434-4656","authenticated-orcid":false,"given":"Ricardo Neves","family":"Marreto","sequence":"additional","affiliation":[{"name":"Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Department of Oral Medicine, Porto Alegre Clinics Hospital (HCPA\/UFRGS) Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Experimental Pathology Unit, Clinics Hospital of Porto Alegre Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.06.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.016"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"05","article-title":"Herbs in oral mucositis","volume":"11","author":"Baharvand M.","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_9_5_1","first-page":"1204","article-title":"Telmisartan modulates the oral mucositis induced by 5\u2010fluoracil in hamsters","volume":"9","author":"Barbosa M. 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