{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:42:52Z","timestamp":1788446572232,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Dyslipidemia is a leading cause of endothelial dysfunction and cardiovascular disease. Several studies used silymarin as an herbal supplement in hyperlipidemic subjects. The aim of the present systematic review and meta\u2010analysis was to examine the effect of silymarin supplementation on blood lipids. PubMed, Scopus, Ovid (Cochrane library), ISI Web of Science, and Google Scholar were systematically searched until March 2018 to find intervention studies that examined the impact of silymarin supplementation on blood lipids in adults. Changes in blood lipids and potential sources of between\u2010study variation were extracted. We run a subgroup analysis to determine potential sources of inter\u2010study heterogeneity. Ten clinical trials fulfilled the eligibility criteria. Meta\u2010analysis indicated that silymarin supplementation in combination with other treatments (not silymarin alone) reduced total cholesterol (change: \u221225.45\u00a0mg\/dl; 95% confidence interval [CI] [\u221247.89, \u22123.01\u00a0mg\/dl]) and low\u2010density lipoprotein (change: \u221228.25\u00a0mg\/dl; 95% CI [\u221253.09, \u22123.42\u00a0mg\/dl]). Also, silymarin increased high\u2010density lipoprotein concentration (change: 4.82\u00a0mg\/dl; 95% CI [2.01, 7.63\u00a0mg\/dl]). Blood concentration of triglyceride was significantly after silymarin supplementation in comparison with controls (change: \u221222.55\u00a0mg\/dl; 95% CI [\u221244.32, \u22120.78\u00a0mg\/dl]). Present systematic review and meta\u2010analysis revealed that silymarin supplementation in combination with other treatments had a favorable effect on blood lipids.<\/jats:p>","DOI":"10.1002\/ptr.6287","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T09:56:02Z","timestamp":1551779762000},"page":"871-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of silymarin supplementation on blood lipids: A systematic review and meta\u2010analysis of clinical trials"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-7356","authenticated-orcid":false,"given":"Hamed","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-6579","authenticated-orcid":false,"given":"Amir","family":"Hadi","sequence":"additional","affiliation":[{"name":"Halal Research Center of IRI FDA Tehran Iran"},{"name":"Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Arab","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Moradi","sequence":"additional","affiliation":[{"name":"Halal Research Center of IRI FDA Tehran Iran"},{"name":"Nutritional Sciences Department, School of Nutritional Sciences and Food Technology Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Rouhani","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/107628003322256878"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"4457","article-title":"Anticancer potential of silymarin: From bench to bed side","volume":"26","author":"Agarwal R.","year":"2006","journal-title":"Anticancer Research"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2015.39.2.87"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.06.038"},{"key":"e_1_2_7_6_1","first-page":"69","article-title":"Phytotherapeutic properties of milk thistle seeds: An overview","volume":"1","author":"Bhattacharya S.","year":"2011","journal-title":"Journal of Advanced Pharmacy Education & Research"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12175"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200106000-00008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.69326"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5977"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(09)60022-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.03.050"},{"issue":"12","key":"e_1_2_7_13_1","first-page":"812","article-title":"Effect of silymarin supplementation on glycemic control, lipid profile and insulin resistance in patients with type 2 diabetes mellitus","volume":"3","author":"Elgarf A. 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