{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:44:05Z","timestamp":1791927845218,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Student Research Committee of Shahid Beheshti University of Medical Science"},{"name":"Student Research Committee of Shahid Beheshti University of Medical Science, Tehran, Iran"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>The aim of this study was to evaluate the effects of <jats:styled-content style=\"fixed-case\"><jats:italic>Nigella sativa<\/jats:italic><\/jats:styled-content> (NS) supplementation in patients with ulcerative colitis<jats:bold>.<\/jats:bold> Two grams of NS powder or placebo were consumed for 6\u00a0weeks by 46 patients with active mild to moderate ulcerative colitis. Using valid and common questionnaires of colitis severity and blood sampling, we estimated disease activity index, quality of life, and some of inflammatory and oxidative stress factors at baseline and after 6\u00a0weeks of supplementation<jats:bold>.<\/jats:bold> NS\u2010elevated tumor necrosis factor\u2010alpha and high\u2010sensitivity\u2010c\u2010reactive\u2010protein as well as reduced malondialdehyde (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005, respectively) compared with placebo. There was no significant difference between the two groups in serum total antioxidant capacity and nuclear factor kB levels. Total scores of Simple Clinical Colitis Activity Index Questionnaire and Inflammatory Bowel Disease Questionnaire\u20109 were not different between the two groups; however, stool frequency score decreased significantly in NS group. Further clinical trials with different pattern of NS administration (the amount of total and divided daily doses, either powder type or standard extracts\/oil and different time arrangement) are needed to clarify the vision.<\/jats:p>","DOI":"10.1002\/ptr.6296","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T09:13:47Z","timestamp":1548234827000},"page":"1027-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The effects of <scp><i>Nigella sativa<\/i><\/scp> on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis"],"prefix":"10.1002","volume":"33","author":[{"given":"Mehrnaz","family":"Nikkhah\u2010Bodaghi","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Darabi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Agah","sequence":"additional","affiliation":[{"name":"Colorectal Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-0052","authenticated-orcid":false,"given":"Azita","family":"Hekmatdoost","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5286"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2017.12.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13779"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i16.2529"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04071.x"},{"key":"e_1_2_7_8_1","first-page":"247","article-title":"Inflammatory bowel disease part I: Ulcerative colitis\u2013pathophysiology and conventional and alternative treatment options","volume":"8","author":"Colitis\u2013Pathophysiology, U","year":"2003","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_7_9_1","first-page":"130","article-title":"Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male","volume":"42","author":"Datau E. 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