{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:31:25Z","timestamp":1791919885540,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Diabetes mellitus is the most common metabolic disorder worldwide. This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs\u2010CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double\u2010blind, randomized clinical trial, 80 hyperlipidemic type 2 diabetic patients were divided into turmeric (2,100\u00a0mg powdered rhizome of turmeric daily) and placebo groups for 8\u00a0weeks. Body weight, fasting plasma glucose, hemoglobin A1c (HbA1c), serum insulin, triglyceride (TG), total cholesterol, low density lypoprotein cholesterol (LDL\u2010c), high density lypoprotein cholesterol, apolipoprotein A1, apolipoprotein B, high sensitivity C\u2010reactive protein (hs\u2010CRP), and total antioxidant capacity were measured before and after intervention. Statistical analysis was carried out using paired and independent <jats:italic>t<\/jats:italic> and chi\u2010square tests. Seventy five patients completed the study. The turmeric group showed significant decreases in body weight, TG, and LDL\u2010c compared with baseline (<jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.05). Body mass index, TG, and total cholesterol decreased significantly in the turmeric group compared with the placebo group (<jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.05). No significant changes were observed in other parameters between the two groups after intervention (<jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.05). Turmeric improved some fractions of lipid profile and decreased body weight in hyperlipidemic patients with type 2 diabetes. It had no significant effect on glycemic status, hs\u2010CRP, and total antioxidant capacity in these patients.<\/jats:p>","DOI":"10.1002\/ptr.6312","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T08:19:18Z","timestamp":1552378758000},"page":"1173-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Effect of turmeric on glycemic status, lipid profile, hs\u2010CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients"],"prefix":"10.1002","volume":"33","author":[{"given":"Zohreh","family":"Adab","sequence":"first","affiliation":[{"name":"Nutrition, Faculty of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-0365","authenticated-orcid":false,"given":"Shahryar","family":"Eghtesadi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Reza","family":"Vafa","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraj","family":"Heydari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Endocrinology and Metabolism, Endocrine Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asieh","family":"Shojaii","sequence":"additional","affiliation":[{"name":"Department of Research, Institute for Islamic and Complementary Medicine and School of Traditional Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Haqqani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Arablou","sequence":"additional","affiliation":[{"name":"Nutrition, Department of Nutrition, Faculty of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Eghtesadi","sequence":"additional","affiliation":[{"name":"Tehran Medical Branch, School of Medicine Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"45","article-title":"The effects of cardiac rehabilitation on changes in the lipid profile of Iranian male and female with coronary artery disease refered to Emam Khomeini Hospital complex","volume":"4","author":"Afzalaghaiee E.","year":"2010","journal-title":"Journal of modern rehabilitation"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.012809.104755"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"9","article-title":"The effect of curcumin on inflammation and serum levels of acute phase proteins in arthritic rats","volume":"2","author":"Aghaee Burashan F.","year":"2008","journal-title":"Journal of Qom University of Medical Sciences"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00341.x"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"201","article-title":"The effect of curcumin on lipid level in patients with acute coronary syndrome","volume":"40","author":"Alwi I.","year":"2008","journal-title":"Acta Medica Indonesiana"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2015.01.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.119"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013106527829"},{"issue":"6","key":"e_1_2_10_11_1","first-page":"614","article-title":"The effect of zinc gluconate supplementation on lipid profile and hs\u2010CRP in overweight diabetic patients","volume":"10","author":"Asghari S.","year":"2011","journal-title":"Iranian Journal of Diabetes and Lipid Disorders"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"273","article-title":"Plant\u2010derived health\u2010the effects of turmeric and curcuminoids","volume":"24","author":"Bengmark S. 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