{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:03:55Z","timestamp":1791821035004,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T00:00:00Z","timestamp":1553385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>French maritime pine bark extract (FMPBE; Oligopin\u00ae), a dietary supplement, is rich in procyanidin. The objective of this study was to determine the effects of FMPBE on bone remodeling in postmenopausal osteopenic women. This randomized, double\u2010blinded, placebo\u2010controlled clinical trial was conducted on 40 postmenopausal osteopenic women. Individuals were randomly assigned to either FMPBE (250\u00a0mg\/day,<jats:italic>n<\/jats:italic>\u00a0=\u00a021) or placebo (250\u2010mg starch\/day,<jats:italic>n<\/jats:italic>\u00a0=\u00a019) for 12\u00a0weeks. Biochemical indices, including bone remodeling marker, were assessed before and after the intervention. After the 12\u2010week intervention, that is, FMPBE supplementation, a significant increase in bone alkaline phosphatase (BAP), procollagen type 1 amino\u2010terminal propeptide (P1NP) levels and a significant decrease in C\u2010terminal telopeptide of type I collagen (CTx1) were observed. Compared with the control group, FMPBE supplementation resulted in a significant increase in P1NP (0.015), BAP levels (0.001), and BAP\/CTx1 ratio (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and a significant decrease in CTx1 levels (0.006). FMPBE supplementation for 12\u00a0weeks in postmenopausal osteopenic women produced favorable effects on bone markers. Meanwhile, further research is needed to determine whether FMPBE supplements can be used as a preventive strategy for bone loss in postmenopausal osteopenic women.<\/jats:p>","DOI":"10.1002\/ptr.6320","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T02:35:57Z","timestamp":1553481357000},"page":"1233-1240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of French maritime pine bark extract (Oligopin\u00ae) supplementation on bone remodeling markers in postmenopausal osteopenic women: A randomized clinical trial"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-2449","authenticated-orcid":false,"given":"Seyed Bahman","family":"Panahande","sequence":"first","affiliation":[{"name":"Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics International Campus, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhila","family":"Maghbooli","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Research Center, Neurosciences Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Hossein\u2010nezhad","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory Boston University Medical Campus Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Qorbani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Non\u2010communicable diseases Research center Alborz University of Medical Sciences Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shermineh","family":"Moeini\u2010Nodeh","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Haghi\u2010Aminjan","sequence":"additional","affiliation":[{"name":"Drug and Advanced Sciences Research Center, School of Pharmacy Ardabil University of Medical Sciences Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics International Campus, Tehran University of Medical Sciences Tehran Iran"},{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","volume-title":"Technical data sheet Oligopin","author":"Authors Pec","year":"2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.018"},{"key":"e_1_2_8_4_1","unstructured":"Brussels Belgium.WHO scientific group on the assessment of osteoporosis at primary health care level Summary Meeting Report World Health Organization2004."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24916"},{"key":"e_1_2_8_6_1","first-page":"102011","article-title":"The middle east & Africa regional audit, epidemiology, costs & burden of osteoporosis in","volume":"2011","author":"El\u2010Hajj Fuleihan G.","year":"2011","journal-title":"International Osteoporosis Foundation"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-011-9187-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-007-9078-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.035"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213515190"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211205020205"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/10966200152744472"},{"key":"e_1_2_8_13_1","unstructured":"Internet:http:\/\/www.nof.org\/."},{"issue":"7","key":"e_1_2_8_14_1","first-page":"10893","article-title":"Pycnogenol\u00ae treatment inhibits bone mineral density loss and trabecular deterioration in ovariectomized rats","volume":"8","author":"Huang G.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.210"},{"issue":"9","key":"e_1_2_8_16_1","first-page":"759","article-title":"Prevalence of osteoporosis in Iran: A meta\u2010analysis. 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