{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T04:51:35Z","timestamp":1781412695556,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>The aim of this study was to evaluate the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and\/or radiotherapy. The systematic review was reported according to the Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses. The search was performed in the following database: Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science. A gray literature search was undertaken using Google Scholar, Open Grey, and ProQuest. The methodology of included studies was evaluated by the Meta\u2010Analysis of Statistics Assessment and Review Instrument. After a two\u2010step selection process, four randomized and one nonrandomized clinical trials were included in the analysis. Two studies were categorized as low and three as moderate risk of bias. Turmeric\/curcumin was applied topically as a gel or as a mouthwash. Patients treated with turmeric\/curcumin experienced reduced grade of mucositis, pain, erythema intensity, and ulcerative area. Current evidence suggests that topical application of turmeric or curcumin is effective in controlling signs and symptoms of oral mucositis. Thus, further investigation is required to confirm the promising effect of turmeric and curcumin in oral inflammatory lesions.<\/jats:p>","DOI":"10.1002\/ptr.6326","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T08:50:28Z","timestamp":1551862228000},"page":"1318-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Effects of turmeric and curcumin on oral mucositis: A systematic review"],"prefix":"10.1002","volume":"33","author":[{"given":"Ana Gabriela Costa","family":"Normando","sequence":"first","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Gomes","family":"de Men\u00eases","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Porto","family":"de Toledo","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"},{"name":"Brazilian Centre for Evidence\u2010Based Research, Department of Dentistry Federal University of Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel \u00c1lvares","family":"Borges","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Louren\u00e7o","family":"de Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Elaine Diniz","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-1550","authenticated-orcid":false,"given":"Eliete Neves Silva","family":"Guerra","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1016\/j.oooo.2016.09.187","article-title":"Pp\u2010Safety assessment of a phytomedication based on Bidens pilosa L. and Curcuma longa L. for patients with oral mucositis","volume":"123","author":"Arantes D. 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