{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:20:04Z","timestamp":1792621204134,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>A double\u2010blind, placebo\u2010controlled human trial was conducted to evaluate the safety and efficacy of a standardized oral supplementation of <jats:italic>Boswellin<\/jats:italic>\u00ae, a novel extract of <jats:styled-content style=\"fixed-case\"><jats:italic>Boswellia serrata<\/jats:italic><\/jats:styled-content> extract (BSE) containing 3\u2010acetyl\u201011\u2010keto\u2010\u03b2\u2010boswellic acid (AKBBA) with \u03b2\u2010boswellic acid (BBA). A total of 48 patients with osteoarthritis (OA) of the knee were randomized and allocated to the BSE and placebo groups for intervention. Patients were administered BSE or placebo for a period of 120\u00a0days. The trial results revealed that BSE treatment significantly improved the physical function of the patients by reducing pain and stiffness compared with placebo. Radiographic assessments showed improved knee joint gap and reduced osteophytes (spur) confirming the efficacy of BSE treatment. BSE also significantly reduced the serum levels of high\u2010sensitive C\u2010reactive protein, a potential inflammatory marker associated with OA of the knee. No serious adverse events were reported. This is the first study with BSE conducted for a period of 120\u00a0days, longer than any other previous clinical trial on patients with OA of the knee. The findings provide evidence that biologically active constituents of BSE, namely, AKBBA and BBA, act synergistically to exert anti\u2010inflammatory\/anti\u2010arthritic activity showing improvement in physical and functional ability and reducing the pain and stiffness.<\/jats:p>","DOI":"10.1002\/ptr.6338","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T09:16:36Z","timestamp":1551863796000},"page":"1457-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["A pilot, randomized, double\u2010blind, placebo\u2010controlled trial to assess the safety and efficacy of a novel <scp><i>Boswellia serrata<\/i><\/scp> extract in the management of osteoarthritis of the knee"],"prefix":"10.1002","volume":"33","author":[{"given":"Muhammed","family":"Majeed","sequence":"first","affiliation":[{"name":"Sami Labs Limited Research &amp; Development Division  Bangalore India"},{"name":"Sabinsa Corporation Research &amp; Development Division  Payson Utah"},{"name":"Sabinsa Corporation Research &amp; Development Division  East Windsor New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheen","family":"Majeed","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation Research &amp; Development Division  Payson Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanan K.","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation Research &amp; Development Division  East Windsor New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-4110","authenticated-orcid":false,"given":"Kalyanam","family":"Nagabhushanam","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation Research &amp; Development Division  East Windsor New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586800-000000000-00000"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41334-1_13"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6609e1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh344"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00160-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3075"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.155606"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2813"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.96119"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.12.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.09.026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1078\/094471103321648593"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.73804"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"1413","article-title":"To assess the efficacy & safety of NILIN\u2122 SR tablets in the management of osteoarthritis of knee","volume":"3","author":"Natarajan S.","year":"2012","journal-title":"International Journal of Pharmacy & Life Sciences"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5174"},{"issue":"6","key":"e_1_2_9_18_1","first-page":"509","article-title":"Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property","volume":"43","author":"Pandey R. 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