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A randomized, double\u2010blind, placebo\u2010controlled study was conducted to assess the efficacy of an andrographolide\u2010containing supplement, ParActin\u00ae (300 and 600\u00a0mg daily), on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain reduction in patients with knee osteoarthritis. Joint stiffness, physical function, changes in the SF\u201036 quality of life questionnaire, a fatigue scale, and safety were also evaluated. A total of 103 male and female patients with I\u2010II osteoarthritis of the knee joint were assessed. Patients treated with 300 or 600\u00a0mg\/day of ParActin\u00ae showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group. WOMAC stiffness scores, physical function score, and the fatigue score showed a significant improvement in both ParActin\u00ae\u2010treated groups compared with the placebo group. At the end of the study, the quality of life (SF\u201036 questionnaire) and Functional Assessment of Chronic Illness Therapy (FACIT) scores showed significant improvements in both ParActin\u00ae\u2010treated groups compared with the placebo group.<\/jats:p><jats:p>Overall, it can be concluded that ParActin\u00ae in 300 and 600\u00a0mg\/day dosages were found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.<\/jats:p>","DOI":"10.1002\/ptr.6339","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T09:56:46Z","timestamp":1554890206000},"page":"1469-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A double\u2010blind, randomized, placebo\u2010controlled study to assess the efficacy of <scp><i>Andrographis paniculata<\/i><\/scp> standardized extract (ParActin\u00ae) on pain reduction in subjects with knee 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