{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:16:54Z","timestamp":1791238614245,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver diseases associated with unfavorable metabolic profiles and oxidative stress parameters. This study was designed to determine the effects of purslane seeds consumption with a low\u2010calorie diet on insulin resistance, lipid profile, and oxidative stress indices in patients with NAFLD. This randomized controlled clinical trial was conducted on 54 individuals with NAFLD. Subjects were randomly assigned to consume either 10\u00a0g\/day of purslane seeds sachet before breakfast and dinner in addition to a low\u2010calorie diet (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) or only the low\u2010calorie diet (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) for 8\u00a0weeks. Fasting blood samples were collected at the beginning and end of the study to measure relevant variables. Intake of purslane seeds with the low\u2010calorie diet led to a significant decrease in serum concentrations of fasting blood sugar (FBS; \u22123.52\u00a0\u00b1\u00a010.45 compared with 3.03\u00a0\u00b1\u00a09.01\u00a0mg\/dl, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017), quantitative insulin sensitivity check index (QUICKI; 0.13\u00a0\u00b1\u00a00.27 compared with \u22120.002\u00a0\u00b1\u00a00.016, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017), total cholesterol (4.33\u00a0\u00b1\u00a034.04 compared with 23.48\u00a0\u00b1\u00a029.47\u00a0mg\/dl, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032), and low\u2010density lipoprotein cholesterol (LDL\u2010C; \u22124.35\u00a0\u00b1\u00a022.65 compared with 11.82\u00a0\u00b1\u00a016.08\u00a0mg\/dl, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) after intervention. Compared with the control group, purslane seeds consumption with adherence to a low\u2010calorie diet had beneficial effects on FBS, HOMA\u2010IR, QUICKI, serum total, and LDL\u2010C in patients with NAFLD but did not affect other glycemic, lipid profile, and oxidative stress parameters.<\/jats:p>","DOI":"10.1002\/ptr.6342","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T03:50:09Z","timestamp":1553140209000},"page":"1501-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The clinical effects of purslane (<scp><i>Portulaca oleracea<\/i><\/scp>) seeds on metabolic profiles in patients with nonalcoholic fatty liver disease: A randomized controlled clinical trial"],"prefix":"10.1002","volume":"33","author":[{"given":"Alireza","family":"Gheflati","sequence":"first","affiliation":[{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Adelnia","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-8402","authenticated-orcid":false,"given":"Azadeh","family":"Nadjarzadeh","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178900"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01748.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/296063"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3628-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20734"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/b10787-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30159.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00318-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.061"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7897\/2277-4343.04119"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.10.S21"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37819"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.690"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20251"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.06.020"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"47","article-title":"The effect of purslane seeds on glycemic status and lipid profiles of persons with type 2 diabetes: A randomized controlled cross\u2010over clinical trial","volume":"20","author":"Esmaillzadeh A.","year":"2015","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.18869\/acadpub.rmm.2.2.34"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3058"},{"issue":"56","key":"e_1_2_8_20_1","first-page":"36","article-title":"Evaluation of the reliability and validity of Azad\u2010Fesharaki's physical activity questionnaire (AFPAQ)","volume":"14","author":"Gh F. M.","year":"2011","journal-title":"Arak Medical University Journal"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10030880"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000117161.66394.07"},{"issue":"9","key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"i","DOI":"10.1002\/ptr.2835","article-title":"Retracted: Antiaging effect of purslane herb aqueous extracts and its mechanism of action","volume":"23","author":"Hao H.","year":"2009","journal-title":"Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"582","article-title":"Purslane effect on GLP\u20101 and GLP\u20101 receptor in type 2 diabetes","volume":"5","author":"Heidarzadeh S.","year":"2013","journal-title":"Electronic Physician"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/367838"},{"issue":"3","key":"e_1_2_8_26_1","first-page":"419","article-title":"Purslane extract effects on obesity\u2010induced diabetic rats fed a high\u2010fat diet","volume":"16","author":"Hussein M. A.","year":"2010","journal-title":"Malaysian Journal of Nutrition"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655102317475498"},{"issue":"7","key":"e_1_2_8_28_1","first-page":"448","article-title":"Study of prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes patients in India (SPRINT)","volume":"61","author":"Kalra S.","year":"2013","journal-title":"The Journal of the Association of Physicians of India"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.02.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00203.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.11.001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0840-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.12.2832"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00747-0"},{"issue":"4","key":"e_1_2_8_35_1","first-page":"221","article-title":"Preventive and therapeutic effect of Portulaca oleracea on experimental hyperlipidemia in rabbits","volume":"28","author":"Liu T.","year":"1997","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800571"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.03.015"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060164"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50229"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01091224"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12550"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2007.285.289"},{"issue":"4","key":"e_1_2_8_43_1","first-page":"163","article-title":"The effect of purslane seeds on fasting blood glucose and serum liver enzymes in patients with nonalcoholic fatty livers","volume":"7","author":"Najafabadi E. A.","year":"2015","journal-title":"Iranian Journal of Diabetes & Obesity (IJDO)"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-122782"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91169-7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28157"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0840"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00194-6"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27126"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00034-X"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2014.68.195-199"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i2.271"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00073-9"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.126"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.2202\/1553-3840.1181"},{"issue":"2","key":"e_1_2_8_56_1","first-page":"52","article-title":"The role of carbohydrate related factors in pathogenesis of nonalcoholic fatty liver disease","volume":"2","author":"Sherafatmanesh S.","year":"2017","journal-title":"International Journal of Nutrition Sciences"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2790"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1992.10718240"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.003871"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912063"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80287-5"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2015.0090"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-7802.166505"},{"issue":"55","key":"e_1_2_8_64_1","first-page":"48","article-title":"The effect of Physalis alkekengi extracts on lipids concentrations in rats","volume":"14","author":"Zarei A.","year":"2011","journal-title":"Journal of Arak University of Medical Sciences"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i29.3377"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:32:13Z","timestamp":1693902733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,20]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/ptr.6342"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6342","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,20]]},"assertion":[{"value":"2018-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}