{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:23:29Z","timestamp":1776068609085,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Pharmacological studies have shown that various species of <jats:styled-content style=\"fixed-case\"><jats:italic>Ficus<\/jats:italic><\/jats:styled-content> have antiviral, antidiarrheal, antipyretic, hypolipidemic, antidiabetic, antioxidant, anticancer, antiparasitic, antiangiogenic, anti\u2010inflammatory, antibacterial, antiplatelet, reproductive, dermatological, immunological, endocrine, and hepato and nephron protective effects. But there is no sufficient research on biomolecules present in the leaf extract of <jats:styled-content style=\"fixed-case\"><jats:italic>Ficus religiosa<\/jats:italic><\/jats:styled-content> and its mechanism of action. We have previously reported that bioavailable constituents of <jats:styled-content style=\"fixed-case\"><jats:italic>F<\/jats:italic>.\u00a0<jats:italic>religiosa<\/jats:italic><\/jats:styled-content> leaf extract exert photosensitizing and apoptosis\u2010inducing capability through the generation of intracellular reactive oxygen species on breast cancer cells. In this review, we have evaluated the expression of checkpoint proteins of G1\/S and sub G0 phase with wet lab data and also have done a data mining of other research for other potential mechanistic action of the <jats:styled-content style=\"fixed-case\"><jats:italic>F<\/jats:italic>.\u00a0<jats:italic>religiosa<\/jats:italic><\/jats:styled-content> leaf extract.<\/jats:p>","DOI":"10.1002\/ptr.6348","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T03:01:21Z","timestamp":1554174081000},"page":"1597-1603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp><i>Ficus<\/i><\/scp> extract\u2014A promising agent for antimammary tumorigenesis: A review on current status and future possibilities"],"prefix":"10.1002","volume":"33","author":[{"given":"Viji","family":"Remadevi","sequence":"first","affiliation":[{"name":"Cancer Research Program Rajiv Gandhi Centre for Biotechnology (RGCB)  Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Mohan Lathika","sequence":"additional","affiliation":[{"name":"Cancer Research Program Rajiv Gandhi Centre for Biotechnology (RGCB)  Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjana","family":"Sasikumar Sujatha","sequence":"additional","affiliation":[{"name":"Cancer Research Program Rajiv Gandhi Centre for Biotechnology (RGCB)  Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-6545","authenticated-orcid":false,"given":"Sreeja","family":"Sreeharshan","sequence":"additional","affiliation":[{"name":"Cancer Research Program Rajiv Gandhi Centre for Biotechnology (RGCB)  Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1147","article-title":"Use of bioactive plant products in combination with standard antibiotics, implications in antimicrobial chemotherapy","volume":"3","author":"Aiyegoro O. 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